ArticleGenetics1999
High-resolution mapping of quantitative trait loci for sternopleural bristle number in Drosophila melanogaster.
Article in Genetics, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed.
- Pleiotropy, epistasis and the genetic architecture of quantitative traits.Nature reviews. Genetics · 2024Review
- Natural Genetic Variation and Candidate Genes for Morphological Traits in Drosophila melanogaster.PloS one · 2016Article
- Article
- An intra-specific linkage map of lettuce (Lactuca sativa) and genetic analysis of postharvest discolouration traits.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2013Article
- A test for selection employing quantitative trait locus and mutation accumulation data.Genetics · 2012Article
- Extensive epistasis for olfactory behaviour, sleep and waking activity in Drosophila melanogaster.Genetics research · 2012Article
- A new mapping method for quantitative trait loci of silkworm.BMC genetics · 2011Article
- Epistasis: obstacle or advantage for mapping complex traits?PloS one · 2010Article
- Mutations and quantitative genetic variation: lessons from Drosophila.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2010Review
- Genetical toxicogenomics in Drosophila identifies master-modulatory loci that are regulated by developmental exposure to lead.Neurotoxicology · 2009Article
- Genetic architecture of quantitative traits in mice, flies, and humans.Genome research · 2009Article
- Variations at a quantitative trait locus (QTL) affect development of behavior in lead-exposed Drosophila melanogaster.Neurotoxicology · 2009Article
- Is genetic evolution predictable?Science (New York, N.Y.) · 2009Review
- Article
- Joint estimates of quantitative trait locus effect and frequency using synthetic recombinant populations of Drosophila melanogaster.Genetics · 2007Article
- Quantitative trait loci with age-specific effects on fecundity in Drosophila melanogaster.Genetics · 2006Article
- Polygenic mutation in Drosophila melanogaster: Mapping spontaneous mutations affecting sensory bristle number.Genetics · 2005Article
- Drosophila bristles and the nature of quantitative genetic variation.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2005Review
- Selection in backcross programmes.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2005Review
- Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
We have mapped quantitative trait loci (QTL) harboring naturally occurring allelic variation for Drosophila bristle number. Lines with high (H) and low (L) sternopleural bristle number were derived by artificial selection from a large base population. Isogenic H and L sublines were extracted from the selection lines, and populations of X and third chromosome H/L recombinant isogenic lines were constructed in the homozygous low line background. The polymorphic cytological locations of roo transposable elements provided a dense molecular marker map with an average intermarker distance of 4.5 cM. Two X chromosome and six chromosome 3 QTL affecting response to selection for sternopleural bristle number and three X chromosome and three chromosome 3 QTL affecting correlated response in abdominal bristle number were detected using a composite interval mapping method. The average effects of bristle number QTL were moderately large, and some had sex-specific effects. Epistasis between QTL affecting sternopleural bristle number was common, and interaction effects were large. Many of the intervals containing bristle number QTL coincided with those mapped in previous studies. However, resolution of bristle number QTL to the level of genetic loci is not trivial, because the genomic regions containing bristle number QTL often did not contain obvious candidate loci, and results of quantitative complementation tests to mutations at candidate loci affecting adult bristle number were ambiguous.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.