ArticleGenetics1999
Genetics of nitrogen regulation in Methanococcus maripaludis.
Article in Genetics, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 84 citations in OpenAlex.
- Article
- Nitrogen fixation by methanogenic Archaea, literature review and DNA database-based analysis; significance in face of climate change.Archives of microbiology · 2024Review
- Article
- An improved CRISPR and CRISPR interference (CRISPRi) toolkit for engineering the model methanogenic archaeon Methanococcus maripaludis.Microbial cell factories · 2024Article
- Expression of V-nitrogenase and Fe-nitrogenase inApplied and environmental microbiology · 2023Article
- The minimal SUF system is not required for Fe-S cluster biogenesis in the methanogenic archaeon Methanosarcina acetivorans.Scientific reports · 2023Article
- Article
- CRISPR-Cas9 Toolkit for Genome Editing in an Autotrophic COMicrobiology spectrum · 2022Article
- Efficient CRISPR/Cas12a-Based Genome-Editing Toolbox for Metabolic Engineering inACS synthetic biology · 2022Article
- A Genetic Study ofMicrobiology spectrum · 2022Article
- Transcriptional response to prolonged perchlorate exposure in the methanogen Methanosarcina barkeri and implications for Martian habitability.Scientific reports · 2021Article
- NifA is the master regulator of both nitrogenase systems in Rhodobacter capsulatus.MicrobiologyOpen · 2019Article
- Bioaugmentation of soil with3 Biotech · 2019Article
- Metabolic processes of Methanococcus maripaludis and potential applications.Microbial cell factories · 2016Review
- Activity and interactions of methane seep microorganisms assessed by parallel transcription and FISH-NanoSIMS analyses.The ISME journal · 2016Article
- Flux measurements and maintenance energy for carbon dioxide utilization by Methanococcus maripaludis.Microbial cell factories · 2015Article
- Evidence that biosynthesis of the second and third sugars of the archaellin Tetrasaccharide in the archaeon Methanococcus maripaludis occurs by the same pathway used by Pseudomonas aeruginosa to make a di-N-acetylated sugar.Journal of bacteriology · 2015Article
- Microbial communities involved in biological ammonium removal from coal combustion wastewaters.Microbial ecology · 2013Article
- Nontarget effects of foliar fungicide application on the rhizosphere: diversity of nifH gene and nodulation in chickpea field.Journal of applied microbiology · 2012Article
- Identification of genes involved in the acetamidino group modification of the flagellin N-linked glycan of Methanococcus maripaludis.Journal of bacteriology · 2012Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
We have used genetic methods in Methanococcus maripaludis to study nitrogen metabolism and its regulation. We present evidence for a "nitrogen regulon" in Methanococcus and Methanobacterium species containing genes of nitrogen metabolism that are regulated coordinately at the transcriptional level via a common repressor binding site sequence, or operator. The implied mechanism for regulation resembles the general bacterial paradigm for repression, but contrasts with well-known mechanisms of nitrogen regulation in bacteria, which occur by activation. Genes in the nitrogen regulons include those for nitrogen fixation, glutamine synthetase, (methyl)ammonia transport, the regulatory protein GlnB, and ammonia-dependent NAD synthetase, as well as a gene of unknown function. We also studied the function of two novel GlnB homologues that are encoded within the nif gene cluster of diazotrophic methanogens. The phenotype resulting from a glnB null mutation in M. maripaludis provides direct evidence that glnB-like genes are involved in "ammonia switch-off," the post-transcriptional inhibition of nitrogen fixation upon addition of ammonia. Finally, we show that the gene nifX is not required for nitrogen fixation, in agreement with findings in several bacteria. These studies illustrate the utility of genetic methods in M. maripaludis and show the enhanced perspective that studies in the Archaea can bring to known biological systems.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.