ArticleThe Journal of experimental medicine1999
Structure of human histocompatibility leukocyte antigen (HLA)-Cw4, a ligand for the KIR2D natural killer cell inhibitory receptor.
Article in The Journal of experimental medicine, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 52 citations in OpenAlex.
- Post-translational modification of NK cell receptors offers clues to antigenic specificity riddle.Frontiers in immunology · 2025Review
- Principles of peptide selection by the transporter associated with antigen processing.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Prediction and identification of T cell epitopes of COVID-19 with balanced cytokine response for the development of peptide based vaccines.In silico pharmacology · 2021Article
- Peptide-Based Subunit Vaccine Design of T- and B-Cells Multi-Epitopes against Zika Virus Using Immunoinformatics Approaches.Microorganisms · 2019Article
- The molecular basis for peptide repertoire selection in the human leucocyte antigen (HLA) C*06:02 molecule.The Journal of biological chemistry · 2017Article
- Shared peptide binding of HLA Class I and II alleles associate with cutaneous nevirapine hypersensitivity and identify novel risk alleles.Scientific reports · 2017Article
- Uncovering the peptide-binding specificities of HLA-C: a general strategy to determine the specificity of any MHC class I molecule.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- Host-specific adaptation of HIV-1 subtype B in the Japanese population.Journal of virology · 2014Article
- Dynamics of free versus complexed β2-microglobulin and the evolution of interfaces in MHC class I molecules.Immunogenetics · 2013Article
- HLA-C and HIV-1: friends or foes?Retrovirology · 2012Review
- Signatures of historical demography and pathogen richness on MHC class I genes.Immunogenetics · 2012Article
- Impact of a functional KIR2DS4 allele on heterosexual HIV-1 transmission among discordant Zambian couples.The Journal of infectious diseases · 2011Article
- HLA mismatches and hematopoietic cell transplantation: structural simulations assess the impact of changes in peptide binding specificity on transplant outcome.Immunome research · 2011Article
- Conformational changes within the HLA-A1:MAGE-A1 complex induced by binding of a recombinant antibody fragment with TCR-like specificity.Protein science : a publication of the Protein Society · 2009Article
- In silico characterization of immunogenic epitopes presented by HLA-Cw*0401.Immunome research · 2007Article
- A novel method for KIR-ligand typing by pyrosequencing to predict NK cell alloreactivity.Clinical immunology (Orlando, Fla.) · 2007Article
- EpiJen: a server for multistep T cell epitope prediction.BMC bioinformatics · 2006Article
- The human natural killer cell immune synapse.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- Expression of NKp46 and other activating inhibitory receptors on uterine endometrial NK cells in females with various reproductive failures: A review.Reproductive medicine and biologyReview
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The crystal structure of the human class I major histocompatibility complex molecule, human histocompatibility leukocyte antigen (HLA)-Cw4, the ligand for a natural killer (NK) cell inhibitory receptor, has been determined, complexed with a nonameric consensus peptide (QYDDAVYKL). Relative to HLA-A2, the peptide binding groove is widened around the COOH terminus of the alpha 1 helix, which contains residues that determine the specificity of HLA-Cw4 for the inhibitory NK receptor, KIR2D. The structure reveals an unusual pattern of internal hydrogen bonding among peptide residues. The peptide is anchored in four specificity pockets in the cleft and secured by extensive hydrogen bonds between the peptide main chain and the cleft. The surface of HLA-Cw4 has electrostatic complementarity to the surface of the NK cell inhibitory receptor KIR2D.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.