ArticleThe Journal of experimental medicine1999
Stem cell emergence and hemopoietic activity are incompatible in mouse intraembryonic sites.
Article in The Journal of experimental medicine, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
43 citing papers in PubMed.
- Flow-Induced Yap/Taz Signaling Balances Endothelial and Hematopoietic Stem Cell Fates.bioRxiv : the preprint server for biology · 2026Article
- Spatiotemporal dynamics of fetal liver hematopoietic niches.The Journal of experimental medicine · 2025Article
- Review
- How cell migration helps immune sentinels.Frontiers in cell and developmental biology · 2022Review
- Megakaryocyte production is sustained by direct differentiation from erythromyeloid progenitors in the yolk sac until midgestation.Immunity · 2021Article
- JEM career launchpad.The Journal of experimental medicine · 2021Article
- The mechanisms of pathological extramedullary hematopoiesis in diseases.Cellular and molecular life sciences : CMLS · 2020Review
- Hematopoiesis: A Layered Organization Across Chordate Species.Frontiers in cell and developmental biology · 2020Review
- Activation of the vitamin D receptor transcription factor stimulates the growth of definitive erythroid progenitors.Blood advances · 2018Article
- Regulation of the hematopoietic stem cell lifecycle by the endothelial niche.Current opinion in hematology · 2017Review
- Embryonic Intra-Aortic Clusters Undergo Myeloid Differentiation Mediated by Mesonephros-Derived CSF1 in Mouse.Stem cell reviews and reports · 2016Article
- Mll-AF4 Confers Enhanced Self-Renewal and Lymphoid Potential during a Restricted Window in Development.Cell reports · 2016Article
- Article
- Development and differentiation of the erythroid lineage in mammals.Developmental and comparative immunology · 2016Review
- Human definitive haemogenic endothelium and arterial vascular endothelium represent distinct lineages.Nature cell biology · 2015Article
- Localized SCF and IGF-1 secretion enhances erythropoiesis in the spleen of murine embryos.Biology open · 2015Article
- Two waves of distinct hematopoietic progenitor cells colonize the fetal thymus.Nature immunology · 2014Article
- Erythroid development in the mammalian embryo.Blood cells, molecules & diseases · 2013Review
- Concise Review: early embryonic erythropoiesis: not so primitive after all.Stem cells (Dayton, Ohio) · 2013Review
- Notch1 activation in embryonic VE-cadherin populations selectively blocks hematopoietic stem cell generation and fetal liver hematopoiesis.Transgenic research · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the mouse embryo, the generation of candidate progenitors for long-lasting hemopoiesis has been reported in the paraaortic splanchnopleura (P-Sp)/ aorta-gonad-mesonephros (AGM) region. Here, we address the following question: can the P-Sp/AGM environment support hemopoietic differentiation as well as generate stem cells, and, conversely, are other sites where hemopoietic differentiation occurs capable of generating stem cells? Although P-Sp/AGM generates de novo hemopoietic stem cells between 9.5 and 12.5 days post coitus (dpc), we show here that it does not support hemopoietic differentiation. Among mesoderm-derived sites, spleen and omentum were shown to be colonized by exogenous cells in the same fashion as the fetal liver. Cells colonizing the spleen were multipotent and pursued their evolution to committed progenitors in this organ. In contrast, the omentum, which was colonized by lymphoid-committed progenitors that did not expand, cannot be considered as a hemopoietic organ. From these data, stem cell generation appears incompatible with hemopoietic activity. At the peak of hemopoietic progenitor production in the P-Sp/AGM, between 10.5 and 11.5 dpc, multipotent cells were found at the exceptional frequency of 1 out of 12 total cells and 1 out of 4 AA4.1+ cells. Thus, progenitors within this region constitute a pool of undifferentiated hemopoietic cells readily accessible for characterization.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.