ArticleJapanese journal of cancer research : Gann1999
Roles of extracellular signal-regulated kinase 1/2 and p38 mitogen-activated protein kinase in the signal transduction of basic fibroblast growth factor in endothelial cells during angiogenesis.
Article in Japanese journal of cancer research : Gann, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 124 citations in OpenAlex.
- The construction of a microenvironment with the vascular network by co-culturing fibroblasts and endothelial cells.Regenerative therapy · 2024Article
- The Effect of Ketogenic Diet on Shared Risk Factors of Cardiovascular Disease and Cancer.Nutrients · 2022Review
- bFGF-mediated phosphorylation of δ-catenin increases its protein stability and the ability to induce the nuclear redistribution of β-catenin.American journal of cancer research · 2021Article
- Transcriptomic Bioinformatic Analyses of Atria Uncover Involvement of Pathways Related to Strain and Post-translational Modification of Collagen in Increased Atrial Fibrillation Vulnerability in Intensely Exercised Mice.Frontiers in physiology · 2020Article
- The proinflammatory cytokine, IL-6, and its interference with bFGF signaling and PSMA in prostate cancer cells.Inflammation · 2013Article
- LY2228820 dimesylate, a selective inhibitor of p38 mitogen-activated protein kinase, reduces angiogenic endothelial cord formation in vitro and in vivo.The Journal of biological chemistry · 2013Article
- Inhibition of angiogenesis mediated by extremely low-frequency magnetic fields (ELF-MFs).PloS one · 2013Article
- Signaling regulation of fetoplacental angiogenesis.The Journal of endocrinology · 2012Review
- Nanotopographical modification: a regulator of cellular function through focal adhesions.Nanomedicine : nanotechnology, biology, and medicine · 2010Review
- Sulfatase activities towards the regulation of cell metabolism and signaling in mammals.Cellular and molecular life sciences : CMLS · 2010Review
- Membrane type-1 matrix metalloproteinase potentiates basic fibroblast growth factor-induced corneal neovascularization.The American journal of pathology · 2009Article
- Novel therapeutic strategy for uterine endometrial cancers.International journal of clinical oncology · 2008Review
- CTRP3/cartducin promotes proliferation and migration of endothelial cells.Molecular and cellular biochemistry · 2007Article
- Bone morphogenetic protein 2 (BMP-2) and induction of tumor angiogenesis.Journal of cancer research and clinical oncology · 2005Article
- Contribution of the p38MAPK signalling pathway to proliferation in human cultured airway smooth muscle cells is mitogen-specific.British journal of pharmacology · 2004Article
- Nuclear factor of activated T cells balances angiogenesis activation and inhibition.The Journal of experimental medicine · 2004Article
- Cyclosporin A differentially inhibits multiple steps in VEGF induced angiogenesis in human microvascular endothelial cells through altered intracellular signaling.Cell communication and signaling : CCS · 2004Article
- Downregulation of uPA, uPAR and MMP-9 using small, interfering, hairpin RNA (siRNA) inhibits glioma cell invasion, angiogenesis and tumor growth.Neuron glia biology · 2004Article
- Transcription factor Ets-1 mediates ischemia- and vascular endothelial growth factor-dependent retinal neovascularization.The American journal of pathology · 2004Article
- Clinical implications of expression of ETS-1 in relation to angiogenesis in ovarian cancers.Cancer science · 2003Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We examined the role of mitogen-activated protein (MAP) kinases in the signal transduction of basic fibroblast growth factor (bFGF)-mediated effects in endothelial cells (ECs). When MSS31 murine endothelial cells were stimulated with bFGF, three MAP kinase homologs, extracellular signal-regulated kinase (ERK) 1/2, c-Jun N-terminal kinase (JNK) 1, and p38 MAP kinase were activated. The inhibition of the ERK1/2 pathway with PD98059, a specific inhibitor of MEK1, or of the p38 MAP kinase pathway with SB203580, a specific inhibitor of p38 MAP kinase, abrogated bFGF-mediated tube formation by MSS31 cells in type I collagen gel. Tube formation in type I collagen gel requires proliferation and migration of these cells, and degradation of the extracellular matrix by these cells. Both PD98059 and SB203580 inhibited bFGF-stimulated DNA synthesis as well as migration of MSS31 cells. Cell migration requires cytoskeleton reorganization and cell adhesion. bFGF induced actin reorganization and vinculin assembly in the focal adhesion plaque, both of which were inhibited by SB203580 but not by PD98059. bFGF induced the expression of the transcription factor ETS-1 in MSS31 cells. ETS-1 is responsible for the expression of proteases as well as integrin beta 3 subunit in ECs, and converts ECs to invasive phenotype. PD98059 inhibited this induction of ETS-1, whereas SB203580 did not. These results indicate that ERK1/2 and p38 MAP kinase are requisite for the signal transduction of bFGF in ECs. The roles of these two MAP kinase homologs are not identical, but these kinases work in a coordinated fashion.
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