ArticleAntimicrobial agents and chemotherapy1999
Effects of the human immunodeficiency virus (HIV) proteinase inhibitors saquinavir and indinavir on in vitro activities of secreted aspartyl proteinases of Candida albicans isolates from HIV-infected patients.
Article in Antimicrobial agents and chemotherapy, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 131 citations in OpenAlex.
- Secreted Aspartic Proteinases: Key Factors inInternational journal of molecular sciences · 2024Review
- Structural determinants for subnanomolar inhibition of the secreted aspartic protease Sapp1p fromJournal of enzyme inhibition and medicinal chemistry · 2021Article
- Repositioning Lopinavir, an HIV Protease Inhibitor, as a Promising Antifungal Drug: Lessons Learned fromJournal of fungi (Basel, Switzerland) · 2021Article
- In vitro three-dimensional organotypic culture models of the oral mucosa.In vitro cellular & developmental biology. Animal · 2021Review
- Evaluation of Antifungal Activity ofToxins · 2020Article
- Virulence and biofilms as promising targets in developing antipathogenic drugs against candidiasis.Future science OA · 2020Review
- Combination of Antifungal Drugs and Protease Inhibitors PreventFrontiers in microbiology · 2020Article
- Secreted aspartyl proteinase (PbSap) contributes to the virulence of Paracoccidioides brasiliensis infection.PLoS neglected tropical diseases · 2018Article
- Chemical inhibitors of Candida albicans hyphal morphogenesis target endocytosis.Scientific reports · 2017Article
- Virulence factors and genetic variability of vaginal Candida albicans isolates from HIV-infected women in the post-highly active antiretroviral era.Revista do Instituto de Medicina Tropical de Sao Paulo · 2017Article
- Synergistic combinations of antifungals and anti-virulence agents to fight against Candida albicans.Virulence · 2015Review
- Sulfone derivatives reduce growth, adhesion and aspartic protease SAP2 gene expression.World journal of microbiology & biotechnology · 2014Article
- A peptide derived from the highly conserved protein GAPDH is involved in tissue protection by different antifungal strategies and epithelial immunomodulation.The Journal of investigative dermatology · 2013Article
- CD8 T cells and E-cadherin in host responses against oropharyngeal candidiasis.Oral diseases · 2012Article
- Enterolobium contortisiliquum trypsin inhibitor (EcTI), a plant proteinase inhibitor, decreases in vitro cell adhesion and invasion by inhibition of Src protein-focal adhesion kinase (FAK) signaling pathways.The Journal of biological chemistry · 2012Article
- Evaluation of antifungal activity of medicinal plant extracts against oral Candida albicans and proteinases.Mycopathologia · 2011Article
- Protease expression by microorganisms and its relevance to crucial physiological/pathological events.World journal of biological chemistry · 2011Article
- Wild-type Drosophila melanogaster as a model host to analyze nitrogen source dependent virulence of Candida albicans.PloS one · 2011Article
- HIV aspartyl protease inhibitors as promising compounds against Candida albicans André Luis Souza dos Santos.World journal of biological chemistry · 2010Article
- Associations among the use of highly active antiretroviral therapy, oral candidiasis, oral Candida species and salivary immunoglobulin A in HIV-infected children.Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics · 2009Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The effects of therapeutically relevant concentrations of the human immunodeficiency virus (HIV) proteinase inhibitors saquinavir and indinavir on the in vitro proteinase activity of Candida albicans were investigated with isolates from HIV-infected and uninfected patients with oral candidiasis. After exposure to the HIV proteinase inhibitors, proteinase activity was significantly reduced in a dose-dependent manner. These inhibitory effects, which were similar to that of pepstatin A, and the reduced virulence phenotype in experimental candidiasis after application of saquinavir indicate the usefulness of these HIV proteinase inhibitors as potential anticandidal agents.
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