ArticleAntimicrobial agents and chemotherapy1999
Emergence of drug-resistant populations of woodchuck hepatitis virus in woodchucks treated with the antiviral nucleoside lamivudine.
Article in Antimicrobial agents and chemotherapy, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 85 citations in OpenAlex.
- Biographical Feature: William (Bill) S. Mason.Journal of virology · 2023Article
- Application of the woodchuck animal model for the treatment of hepatitis B virus-induced liver cancer.World journal of gastrointestinal oncology · 2021Review
- Article
- The Woodchuck, a Nonprimate Model for Immunopathogenesis and Therapeutic Immunomodulation in Chronic Hepatitis B Virus Infection.Cold Spring Harbor perspectives in medicine · 2015Review
- Infection Patterns Induced in Naive Adult Woodchucks by Virions of Woodchuck Hepatitis Virus Collected during either the Acute or Chronic Phase of Infection.Journal of virology · 2015Article
- Capacity of a natural strain of woodchuck hepatitis virus, WHVNY, to induce acute infection in naive adult woodchucks.Virus research · 2015Article
- Superinfection with woodchuck hepatitis virus strain WHVNY of livers chronically infected with strain WHV7.Journal of virology · 2015Article
- The Discovery and Development of a Potent Antiviral Drug, Entecavir, for the Treatment of Chronic Hepatitis B.Journal of clinical and translational hepatology · 2013Review
- Viral resistance in hepatitis B: prevalence and management.Current gastroenterology reports · 2010Article
- Antiviral resistance and hepatitis B therapy.Hepatology (Baltimore, Md.) · 2009Article
- Antiviral effects of lamivudine, emtricitabine, adefovir dipivoxil, and tenofovir disoproxil fumarate administered orally alone and in combination to woodchucks with chronic woodchuck hepatitis virus infection.Antimicrobial agents and chemotherapy · 2008Article
- The woodchuck as an animal model for pathogenesis and therapy of chronic hepatitis B virus infection.World journal of gastroenterology · 2007Review
- Clinical emergence of entecavir-resistant hepatitis B virus requires additional substitutions in virus already resistant to Lamivudine.Antimicrobial agents and chemotherapy · 2004Article
- Entecavir therapy combined with DNA vaccination for persistent duck hepatitis B virus infection.Antimicrobial agents and chemotherapy · 2003Article
- Generation of stable cell lines expressing Lamivudine-resistant hepatitis B virus for antiviral-compound screening.Antimicrobial agents and chemotherapy · 2003Article
- Mutations of the woodchuck hepatitis virus polymerase gene that confer resistance to lamivudine and 2'-fluoro-5-methyl-beta-L-arabinofuranosyluracil.Journal of virology · 2002Article
- Antiviral activity of beta-L-2',3'-dideoxy-2',3'-didehydro-5-fluorocytidine in woodchucks chronically infected with woodchuck hepatitis virus.Antimicrobial agents and chemotherapy · 2001Article
- Kinetics of hepadnavirus loss from the liver during inhibition of viral DNA synthesis.Journal of virology · 2001Article
- Combination therapy with lamivudine and adenovirus causes transient suppression of chronic woodchuck hepatitis virus infections.Journal of virology · 2000Article
- Low dynamic state of viral competition in a chronic avian hepadnavirus infection.Journal of virology · 2000Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Lamivudine [(-)-beta-L-2',3'-dideoxy-3'-thiacytidine] reduces woodchuck hepatitis virus (WHV) titers in the sera of chronically infected woodchucks by inhibiting viral DNA synthesis. However, after 6 to 12 months, WHV titers begin to increase toward pretreatment levels. Three WHV variants with mutations in the active site of the DNA polymerase gene are present at this time (W. S. Mason et al., Virology 245:18-32, 1998). We have asked if these mutant viruses were responsible for the lamivudine resistance and if their emergence caused an immediate rise in virus titers. Cell cultures studies implied that the mutants were resistant to lamivudine. Emergence of mutant WHV was not always associated, however, with an immediate rise in virus titers in the serum. One of the three types of mutant viruses became prominent in serum up to 7 months before titers in serum actually began to increase, at a time when wild-type virus was still predominant in the liver. The two other mutants did not show this behavior but were detected in serum and liver later, just at the time that virus titers began to rise. A factor linking all three mutants was that a similar duration of drug administration preceded the rise in titers, irrespective of which mutant ultimately prevailed. A simple explanation for these results is that the increase in virus titers following emergence of drug-resistant mutants can occur only as the preexisting wild-type virus is cleared from the hepatocyte population, allowing spread of the mutants. Thus, prolonged suppression of virus titers in the serum may sometimes be a measure of the stability of hepatocyte infection rather than of a successful therapeutic outcome.
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