ArticleThe Journal of cell biology1999
DAip1, a Dictyostelium homologue of the yeast actin-interacting protein 1, is involved in endocytosis, cytokinesis, and motility.
Article in The Journal of cell biology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed, 128 citations in OpenAlex.
- Platelet WDR1 suppresses platelet activity and is associated with cardiovascular disease.Blood · 2016Trial
- Counting actin in contractile rings reveals novel contributions of cofilin and type II myosins to fission yeast cytokinesis.Molecular biology of the cell · 2022Article
- The Amoebal Model for Macropinocytosis.Sub-cellular biochemistry · 2022Article
- Formation of Cytoplasmic Actin-Cofilin Rods is Triggered by Metabolic Stress and Changes in Cellular pH.Frontiers in cell and developmental biology · 2021Article
- Ate1-mediated posttranslational arginylation affects substrate adhesion and cell migration in Dictyostelium discoideum.Molecular biology of the cell · 2019Article
- Real-Time Single-Molecule Kinetic Analyses of AIP1-Enhanced Actin Filament Severing in the Presence of Cofilin.Journal of molecular biology · 2019Article
- An actin-depolymerizing factor from the halophyte smooth cordgrass, Spartina alterniflora (SaADF2), is superior to its rice homolog (OsADF2) in conferring drought and salt tolerance when constitutively overexpressed in rice.Plant biotechnology journal · 2019Article
- Functions of actin-interacting protein 1 (AIP1)/WD repeat protein 1 (WDR1) in actin filament dynamics and cytoskeletal regulation.Biochemical and biophysical research communications · 2018Review
- WDR1 predicts poor prognosis and promotes cancer progression in hepatocellular carcinoma.International journal of clinical and experimental pathology · 2018Article
- Actin-Interacting Protein 1 Contributes to Intranuclear Rod Assembly in Dictyostelium discoideum.Scientific reports · 2017Article
- A Diaphanous-related formin links Ras signaling directly to actin assembly in macropinocytosis and phagocytosis.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Aip1 promotes actin filament severing by cofilin and regulates constriction of the cytokinetic contractile ring.The Journal of biological chemistry · 2015Article
- Small GTPases and phosphoinositides in the regulatory mechanisms of macropinosome formation and maturation.Frontiers in physiology · 2014Review
- Two actin-interacting protein 1 isoforms function redundantly in the somatic gonad and are essential for reproduction in Caenorhabditis elegans.Cytoskeleton (Hoboken, N.J.) · 2014Article
- Actin interacting protein1 and actin depolymerizing factor drive rapid actin dynamics in Physcomitrella patens.The Plant cell · 2011Article
- The two actin-interacting protein 1 genes have overlapping and essential function for embryonic development in Caenorhabditis elegans.Molecular biology of the cell · 2011Article
- Paxillin and phospholipase D interact to regulate actin-based processes in Dictyostelium discoideum.Eukaryotic cell · 2011Article
- The professional phagocyte Dictyostelium discoideum as a model host for bacterial pathogens.Current drug targets · 2011Review
- Expression of actin-interacting protein 1 suppresses impaired chemotaxis of Dictyostelium cells lacking the Na+-H+ exchanger NHE1.Molecular biology of the cell · 2010Article
- WDR1 presence in the songbird basilar papilla.Hearing research · 2008Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The 64-kD protein DAip1 from Dictyostelium contains nine WD40-repeats and is homologous to the actin-interacting protein 1, Aip1p, from Saccharomyces cerevisiae, and to related proteins from Caenorhabditis, Physarum, and higher eukaryotes. We show that DAip1 is localized to dynamic regions of the cell cortex that are enriched in filamentous actin: phagocytic cups, macropinosomes, lamellipodia, and other pseudopodia. In cells expressing green fluorescent protein (GFP)-tagged DAip1, the protein rapidly redistributes into newly formed cortical protrusions. Functions of DAip1 in vivo were assessed using null mutants generated by gene replacement, and by overexpressing DAip1. DAip1-null cells are impaired in growth and their rates of fluid-phase uptake, phagocytosis, and movement are reduced in comparison to wild-type rates. Cytokinesis is prolonged in DAip1-null cells and they tend to become multinucleate. On the basis of similar results obtained by DAip1 overexpression and effects of latrunculin-A treatment, we propose a function for DAip1 in the control of actin depolymerization in vivo, probably through interaction with cofilin. Our data suggest that DAip1 plays an important regulatory role in the rapid remodeling of the cortical actin meshwork.
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