ReviewJournal of mammary gland biology and neoplasia1999
Growth factors, apoptosis, and survival of mammary epithelial cells.
Review in Journal of mammary gland biology and neoplasia, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 98 citations in OpenAlex.
- Beyond Milk and Nurture: Breastfeeding's Powerful Impact on Breast Cancer.Geburtshilfe und Frauenheilkunde · 2024Article
- 5-Hydroxytryptophan inhibits β-casein biosynthesis and promotes goat mammary epithelial cell apoptosis through the JAK2/STAT5a axis and the HTR7.Journal of animal science · 2023Article
- Role of Cell Death in Cellular Processes During Odontogenesis.Frontiers in cell and developmental biology · 2021Review
- Article
- Genetic variation in transforming growth factor beta 1 and mammographic density in Singapore Chinese women.Cancer research · 2013Article
- Article
- Novel molecular, cytotoxical, and immunological study on promising and selective anticancer activity of mung bean sprouts.BMC complementary and alternative medicine · 2012Article
- Differential expression of cancer associated proteins in breast milk based on age at first full term pregnancy.BMC cancer · 2012Article
- TGFbeta activates mitogen- and stress-activated protein kinase-1 (MSK1) to attenuate cell death.The Journal of biological chemistry · 2011Article
- Medical comorbidities predict mortality in women with a history of early stage breast cancer.Breast cancer research and treatment · 2010Article
- In vitro culture and characterization of a mammary epithelial cell line from Chinese Holstein dairy cow.PloS one · 2009Article
- Role of insulin-like growth factor binding proteins in mammary gland development.Journal of mammary gland biology and neoplasia · 2008Review
- Consortium analysis of 7 candidate SNPs for ovarian cancer.International journal of cancer · 2008Article
- Review
- Molecular models for the tissue specificity of DNA mismatch repair-deficient carcinogenesis.Nucleic acids research · 2006Review
- MMTV Env encodes an ITAM responsible for transformation of mammary epithelial cells in three-dimensional culture.The Journal of experimental medicine · 2005Article
- Use of three-dimensional basement membrane cultures to model oncogene-induced changes in mammary epithelial morphogenesis.Journal of mammary gland biology and neoplasia · 2004Review
- Increased proteasome-dependent degradation of estrogen receptor-alpha by TGF-beta1 in breast cancer cell lines.Journal of cellular biochemistry · 2003Article
- Inducible dimerization of FGFR1: development of a mouse model to analyze progressive transformation of the mammary gland.The Journal of cell biology · 2002Article
- Tissue architecture and breast cancer: the role of extracellular matrix and steroid hormones.Endocrine-related cancer · 2000Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Programmed cell death (apoptosis) occurs regularly during normal growth and development of the mammary gland. One of the most dramatic examples of apoptosis is evident during the remodeling of the breast that accompanies postlactational involution. Transgenic mouse models have demonstrated that overexpression of polypeptides such as transforming growth factor alpha (TGFalpha) and insulin like growth factor I (IGF-I) can block this remodeling, suggesting that these growth factors may be acting as survival factors for the mammary epithelium. In contrast, transgenic mice that overexpress the growth inhibitor transforming growth factor beta (TGF-beta) show increased apoptosis in the mammary epithelium throughout mammary development, suggestive of a mechanism working to counterbalance the survival factors. Experiments with mammary epithelial cell lines cultured in vitro have confirmed that these growth factors can indeed regulate apoptosis and survival in mammary epithelial cells; EGF, IGF-I, and basic fibroblast growth factor (bFGF) act as survival factors for mammary epithelial cells, while TGF-beta induces their death. In breast cancer, cytotoxic drugs and hormone ablation increase the expression of TGF-beta, which may function to induce cell death by either paracrine or autocrine mechanisms. Lastly, although it has very limited expression in the breast, TNFalpha has been shown to be effective in the rapid, direct induction of cell death in breast cancer cell lines. Together, these studies describe a complex dynamic pattern of cell death-inducing and survival factors that promote the development of the mature mammary gland and that rapidly remodel the tissue after lactation.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.