ReviewJournal of mammary gland biology and neoplasia1999
Functional culture models to study mechanisms governing apoptosis in normal and malignant mammary epithelial cells.
Review in Journal of mammary gland biology and neoplasia, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 78 citations in OpenAlex.
- Engineered basement membrane mimetic hydrogels to study mammary epithelial morphogenesis and invasion.Science advances · 2025Article
- Growth factor dependency in mammary organoids regulates ductal morphogenesis during organ regeneration.Scientific reports · 2022Article
- Electrochemical mapping of oxygenation in the three-dimensional multicellular tumour hemi-spheroid.Proceedings. Mathematical, physical, and engineering sciences · 2019Article
- A Functionally Robust Phenotypic Screen that Identifies Drug Resistance-associated Genes Using 3D Cell Culture.Bio-protocol · 2018Article
- Three-Dimensional Quantification of Spheroid Degradation-Dependent Invasion and Invadopodia Formation.Biological procedures online · 2018Article
- Organoids: A historical perspective of thinking in three dimensions.The Journal of cell biology · 2017Review
- Article
- Photodynamic therapy as an effective therapeutic approach in MAME models of inflammatory breast cancer.Breast cancer research and treatment · 2015Article
- Three-dimensional microenvironment confers enhanced sensitivity to doxorubicin by reducing p53-dependent induction of autophagy.Oncogene · 2015Article
- The microenvironment matters.Molecular biology of the cell · 2014Article
- Quantification of breast cancer cell invasiveness using a three-dimensional (3D) model.Journal of visualized experiments : JoVE · 2014Article
- Breast cancer stem cells transition between epithelial and mesenchymal states reflective of their normal counterparts.Stem cell reports · 2014Article
- Apoptotic cell signaling in cancer progression and therapy.Integrative biology : quantitative biosciences from nano to macro · 2011Review
- Extracellular matrix ligand and stiffness modulate immature nucleus pulposus cell-cell interactions.PloS one · 2011Article
- Evidence that aberrant expression of tissue transglutaminase promotes stem cell characteristics in mammary epithelial cells.PloS one · 2011Article
- Human bone marrow-derived MSCs can home to orthotopic breast cancer tumors and promote bone metastasis.Cancer research · 2010Article
- Dose-dependent induction of distinct phenotypic responses to Notch pathway activation in mammary epithelial cells.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Reduced cell death, invasive and angiogenic features conferred by BRCA1-deficiency in mammary epithelial cells transformed with H-Ras.Cancer biology & therapy · 2009Article
- Increasingly transformed MCF-10A cells have a progressively tumor-like phenotype in three-dimensional basement membrane culture.Cancer cell international · 2009Article
- Bioadhesive hydrogel microenvironments to modulate epithelial morphogenesis.Biomaterials · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Mammary tissue homeostasis depends upon dynamic interactions between the epithelial cells, their microenvironment (including the basement membrane and the stroma), and the tissue architecture, which influence each other reciprocally to regulate growth, death and differentiation in the gland. To study how apoptosis is regulated in normal mammary cells, and to understand its role in breast tumor pathogenesis, we need model systems that recapitulate breast tissue architecture and microenvironment in culture. We have established culture models of primary and established nonmalignant mammary cell lines from both rodent and human, and defined procedures to study how cell and tissue architecture affect signaling by the basement membrane. We show that both a basement membrane and an organized tissue structure are required to achieve sustained mammary cell survival. These models could now be used to investigate how the basement membrane represses apoptosis in normal cells, and how breast cancers become death-resistant.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.