ReviewJournal of mammary gland biology and neoplasia1999
NF-kappaB and apoptosis in mammary epithelial cells.
Review in Journal of mammary gland biology and neoplasia, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 45 citations in OpenAlex.
- Multiple roles for Bcl-3 in mammary gland branching, stromal collagen invasion, involution and tumor pathology.Breast cancer research : BCR · 2022Article
- Rutin protects against lipopolysaccharide-induced mastitis by inhibiting the activation of the NF-κB signaling pathway and attenuating endoplasmic reticulum stress.Inflammopharmacology · 2019Article
- Silencing of PYGB suppresses growth and promotes the apoptosis of prostate cancer cells via the NF‑κB/Nrf2 signaling pathway.Molecular medicine reports · 2018Article
- MUC1 induces M2 type macrophage influx during postpartum mammary gland involution and triggers breast cancer.Oncotarget · 2018Article
- Analysis of human breast milk cells: gene expression profiles during pregnancy, lactation, involution, and mastitic infection.Functional & integrative genomics · 2016Article
- Article
- Lipopolysaccharide disrupts the milk-blood barrier by modulating claudins in mammary alveolar tight junctions.PloS one · 2013Article
- Immunopathology of mastitis: insights into disease recognition and resolution.Journal of mammary gland biology and neoplasia · 2011Review
- Singleminded-2s (Sim2s) promotes delayed involution of the mouse mammary gland through suppression of Stat3 and NFκB.Molecular endocrinology (Baltimore, Md.) · 2011Article
- Activation of nuclear factor kappa B in mammary epithelium promotes milk loss during mammary development and infection.Journal of cellular physiology · 2010Article
- Gene network signaling in hormone responsiveness modifies apoptosis and autophagy in breast cancer cells.The Journal of steroid biochemistry and molecular biology · 2009Article
- Signaling perturbations induced by invading H. pylori proteins in the host epithelial cells: a mathematical modeling approach.Journal of theoretical biology · 2007Article
- Mammary gland involution as a multi-step process.Journal of mammary gland biology and neoplasia · 2007Review
- Prolactin potentiates transforming growth factor alpha induction of mammary neoplasia in transgenic mice.The American journal of pathology · 2006Article
- The alveolar switch: coordinating the proliferative cues and cell fate decisions that drive the formation of lobuloalveoli from ductal epithelium.Breast cancer research : BCR · 2006Review
- Gene expression profiling of mammary gland development reveals putative roles for death receptors and immune mediators in post-lactational regression.Breast cancer research : BCR · 2004Article
- Antiestrogen resistance in breast cancer and the role of estrogen receptor signaling.Oncogene · 2003Review
- NF-kappaB in mammary gland development and breast cancer.Journal of mammary gland biology and neoplasia · 2003Review
- IkB kinase alpha: a link in the chain of the mammary cycle.Breast cancer research : BCR · 2002Article
- Tumour-stromal interactions. Integrins and cell adhesions as modulators of mammary cell survival and transformation.Breast cancer research : BCR · 2001Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A number of transcription factors have been identified as regulators of mammary development, including Stat5 and C/EBPbeta (1-3). In this review we summarize evidence which suggests that the NF-kappaB family of transcription factors also has a role in mammary gland development. NF-kappaB was originally described as a mediator of inflammatory reactions and cellular responses to viral pathogens. More recently it has been shown to possess an anti-apoptotic effect in a variety of cell types by regulating apoptosis-related genes. In the light of this function in other tissues, and the observation that aberrant activation of NF-kappaB can be associated with mammary tumors, we discuss the potential role of this transcription factor in modulating mammary epithelial apoptosis and involution of the mammary gland.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.