Evidence map›Paper›PMID 10424737›Full record

ArticleBritish journal of cancer1999

Expression of vascular endothelial growth factor, matrix metalloproteinase-9 and E-cadherin in the process of lymph node metastasis in oesophageal cancer.

F Sato, Y Shimada, G Watanabe, S Uchida, T Makino, M Imamura

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in British journal of cancer, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it, 75 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Article
  5. Glycosylation: a hallmark of cancer?Glycoconjugate journal · 2017
    Review
  6. Article
  7. Review
  8. Article
  9. Article
  10. Review
  11. Clinicopathological and prognostic role of MMP-9 in esophageal squamous cell carcinoma: a meta-analysis.Chinese journal of cancer research = Chung-kuo yen cheng yen chiu · 2013
    Article
  12. Article
  13. Cyclooxygenase isoenzyme-2 and vascular endothelial growth factor are associated with poor prognosis in esophageal adenocarcinoma.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2012
    Article
  14. Article
  15. Validation of tissue microarray technology in squamous cell carcinoma of the esophagus.Virchows Archiv : an international journal of pathology · 2008
    Article
  16. Article
  17. Increased expression of MMP-2 and MMP-9 in esophageal squamous cell carcinoma.Journal of cancer research and clinical oncology · 2004
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

F SatoDepartment of Surgery and Surgical Basic Science, Graduate School of Medicine, Kyoto University, Japan.
Y Shimada
G Watanabe
S Uchida
T Makino
M Imamura
Kyoto University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lymph node metastasis is a strong independent prognostic factor for oesophageal cancer. The expression of matrix metalloproteinases (MMPs) and reduction of E-cadherin correlate with lymph node metastasis of oesophageal cancer. We previously reported that the expression of vascular endothelial growth factor (VEGF) is associated with lymph node metastasis. This study was designed to determine whether VEGF, MMP-9 and E-cadherin expression is stable or changes in the process of lymph node metastasis of oesophageal cancer. Using immunohistochemistry, we detected VEGF, MMP-9 and E-cadherin expression in paraffin-embedded specimens of oesophageal squamous cell carcinoma. We classified 134 primary tumours and 174 nodal metastases using two different criteria: the absence [Group N(-)] or presence [Group N(+)] of nodal metastasis, and the stage of metastasis--Early Stage (cancer cells < 50% of lymph node) or Late Stage (> or = 50%)--and compared the expression among two groups and among two stages. The expression rates of Group N(-), Group N(+), Early Stage and Late Stage are as follows: VEGF (49%, 74%, 60%, 33%), MMP-9 (76%, 65%, 95%, 69%) and E-cadherin (49%, 24%, 55%, 38%). VEGF expression was down-regulated in Late Stage lymph node metastasis, while MMP-9 expression was elevated in Early Stage metastasis. E-cadherin expression is restored somewhat in Early Stage metastasis, but suppressed again in Late Stage metastasis. These data suggest that the expression of VEGF, MMP-9 and E-cadherin each change in the process of lymph node metastasis in oesophageal cancer, and that the patterns of change are different.

Indexed as

AdultAgedAged, 80 and overCadherinsCollagenasesEndothelial Growth FactorsEsophageal NeoplasmsFemaleHumansKeratinsLymphatic MetastasisLymphokinesMaleMatrix Metalloproteinase 9Middle AgedTumor Suppressor Protein p53CadherinsCollagenasesEndothelial Growth FactorsKeratinsLymphokinesMatrix Metalloproteinase 9Tumor Suppressor Protein p53Vascular Endothelial Growth Factor AVascular Endothelial Growth Factors

Identifiers

PMID10424737
PMCPMC2363062
OpenAlexW2001146267

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.