ArticleBiophysical journal1999
Evolutionary relationship between K(+) channels and symporters.
Article in Biophysical journal, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers.
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Who cites it
65 citing papers in PubMed.
- The Aerobic Denitrification Characteristics of a HalophilicMicroorganisms · 2025Article
- The chloroplast-located HKT transporter plays an important role in fertilization and development in Physcomitrium patens.The Plant journal : for cell and molecular biology · 2025Article
- A High-KInternational journal of molecular sciences · 2023Article
- Dimerisation of the Yeast KInternational journal of molecular sciences · 2022Article
- The role of bacterial transport systems in the removal of host antimicrobial peptides in Gram-negative bacteria.FEMS microbiology reviews · 2022Review
- The Critical Role of Spreading Depolarizations in Early Brain Injury: Consensus and Contention.Neurocritical care · 2022Review
- A Novel High-Affinity Potassium TransporterPlants (Basel, Switzerland) · 2022Article
- Review
- Yeast Trk1 Potassium Transporter Gradually Changes Its Affinity in Response to Both External and Internal Signals.Journal of fungi (Basel, Switzerland) · 2022Article
- Mechanism of high affinity potassium transporter (HKT) towards improved crop productivity in saline agricultural lands.3 Biotech · 2022Review
- Molecular Mechanisms for Bacterial Potassium Homeostasis.Journal of molecular biology · 2021Review
- Cation Transporters ofBiomolecules · 2021Review
- Fluorometric Liposome Screen for Inhibitors of a Physiologically Important Bacterial Ion Channel.Frontiers in microbiology · 2021Article
- TrkA undergoes a tetramer-to-dimer conversion to open TrkH which enables changes in membrane potential.Nature communications · 2020Article
- Overexpression ofGenes · 2018Article
- A Single Amino-Acid Substitution in the Sodium Transporter HKT1 Associated with Plant Salt Tolerance.Plant physiology · 2016Article
- OsHKT1;4-mediated Na(+) transport in stems contributes to Na(+) exclusion from leaf blades of rice at the reproductive growth stage upon salt stress.BMC plant biology · 2016Article
- OsHKT2;2/1-mediated Na(+) influx over K(+) uptake in roots potentially increases toxic Na(+) accumulation in a salt-tolerant landrace of rice Nona Bokra upon salinity stress.Journal of plant research · 2016Article
- Dissecting the Molecular Mechanism of Nucleotide-Dependent Activation of the KtrAB K+ Transporter.PLoS biology · 2016Article
- A structural model for facultative anion channels in an oligomeric membrane protein: the yeast TRK (K(+)) system.Pflugers Archiv : European journal of physiology · 2015Article
5 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The hypothesis is presented that at least four families of putative K(+) symporter proteins, Trk and KtrAB from prokaryotes, Trk1,2 from fungi, and HKT1 from wheat, evolved from bacterial K(+) channel proteins. Details of this hypothesis are organized around the recently determined crystal structure of a bacterial K(+) channel: i. e., KcsA from Streptomyces lividans. Each of the four identical subunits of this channel has two fully transmembrane helices (designated M1 and M2), plus an intervening hairpin segment that determines the ion selectivity (designated P). The symporter sequences appear to contain four sequential M1-P-M2 motifs (MPM), which are likely to have arisen from gene duplication and fusion of the single MPM motif of a bacterial K(+) channel subunit. The homology of MPM motifs is supported by a statistical comparison of the numerical profiles derived from multiple sequence alignments formed for each protein family. Furthermore, these quantitative results indicate that the KtrAB family of symporters has remained closest to the single-MPM ancestor protein. Strong sequence evidence is also found for homology between the cytoplasmic C-terminus of numerous bacterial K(+) channels and the cytoplasm-resident TrkA and KtrA subunits of the Trk and KtrAB symporters, which in turn are homologous to known dinucleotide-binding domains of other proteins. The case for homology between bacterial K(+) channels and the four families of K(+) symporters is further supported by the accompanying manuscript, in which the patterns of residue conservation are demonstrated to be similar to each other and consistent with the known 3D structure of the KcsA K(+) channel.
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