ArticleBiophysical journal1999
Membrane stretch affects gating modes of a skeletal muscle sodium channel.
Article in Biophysical journal, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 1 of them a synthesis that pooled it.
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Who cites it
38 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Meta-Analysis of Mechano-Sensitive Ion Channels in Human Hearts: Chamber- and Disease-Preferential mRNA Expression.International journal of molecular sciences · 2023Pooled it
- A statistical damage model for coupled mechano-electrophysiological axonal injury.PLoS computational biology · 2026Article
- Closed state structure of the pore revealed by uncoupled Shaker KNature communications · 2025Article
- Mechanisms of Traumatic Spinal Cord Injury AIS Grade Conversion.Neurotrauma reports · 2025Review
- Identification of RNA reads encoding different channels in isolated rat ventricular myocytes and the effect of cell stretching on L-type CaBiology direct · 2023Article
- The Voltage-Gated Sodium Channel ineNeuro · 2023Article
- Article
- Article
- β1 and β3 subunits amplify mechanosensitivity of the cardiac voltage-gated sodium channel Nav1.5.Pflugers Archiv : European journal of physiology · 2019Article
- Article
- β1 subunit stabilises sodium channel Nav1.7 against mechanical stress.The Journal of physiology · 2018Article
- Cardiac Mechano-Gated Ion Channels and Arrhythmias.Circulation research · 2016Review
- Mechanosensitive gating of Kv channels.PloS one · 2015Review
- Biophysical implications of lipid bilayer rheometry for mechanosensitive channels.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Coupled left-shift of Nav channels: modeling the Na⁺-loading and dysfunctional excitability of damaged axons.Journal of computational neuroscience · 2012Article
- Altered sodium channel-protein associations in critical illness myopathy.Skeletal muscle · 2012Article
- Mechanistic basis for low threshold mechanosensitivity in voltage-dependent K+ channels.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Spontaneous excitation patterns computed for axons with injury-like impairments of sodium channels and Na/K pumps.PLoS computational biology · 2012Article
- Altered calcium signaling following traumatic brain injury.Frontiers in pharmacology · 2012Article
- Left-shifted nav channels in injured bilayer: primary targets for neuroprotective nav antagonists?Frontiers in pharmacology · 2012Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The alpha subunit of the human skeletal muscle Na(+) channel recorded from cell-attached patches yielded, as expected for Xenopus oocytes, two current components that were stable for tens of minutes during 0.2 Hz stimulation. Within seconds of applying sustained stretch, however, the slower component began decreasing and, depending on stretch intensity, disappeared in 1-3 min. Simultaneously, the faster current increased. The resulting fast current kinetics and voltage sensitivity were indistinguishable from the fast components 1) left after 10 Hz depolarizations, and 2) that dominated when alpha subunit was co-expressed with human beta1 subunit. Although high frequency depolarization-induced loss of slow current was reversible, the stretch-induced slow-to-fast conversion was irreversible. The conclusion that stretch converted a single population of alpha subunits from an abnormal slow to a bona fide fast gating mode was confirmed by using gigaohm seals formed without suction, in which fast gating was originally absent. For brain Na(+) channels, co-expressing G proteins with the channel alpha subunit yields slow gating. Because both stretch and beta1 subunits induced the fast gating mode, perhaps they do so by minimizing alpha subunit interactions with G proteins or with other regulatory molecules available in oocyte membrane. Because of the possible involvement of oocyte molecules, it remains to be determined whether the Na(+) channel alpha subunit was directly or secondarily susceptible to bilayer tension.
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