ArticleChromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology1999
Multiple causes of size variation in the diploid megabase chromosomes of African tyrpanosomes.
Article in Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 42 citations in OpenAlex.
- Keeping Balance Between Genetic Stability and Plasticity at the Telomere and Subtelomere ofFrontiers in cell and developmental biology · 2021Review
- Telomere and Subtelomere R-loops and Antigenic Variation in Trypanosomes.Journal of molecular biology · 2020Review
- Telomeric Repeat-Binding Factor Homologs inFrontiers in cellular and infection microbiology · 2018Article
- Sexual reproduction and genetic exchange in parasitic protists.Parasitology · 2015Review
- Chromosome level assembly of the hybrid Trypanosoma cruzi genome.BMC genomics · 2009Article
- Evolutionary consequences of a large duplication event in Trypanosoma brucei: chromosomes 4 and 8 are partial duplicons.BMC genomics · 2007Article
- Hemizygous subtelomeres of an African trypanosome chromosome may account for over 75% of chromosome length.Genome research · 2006Article
- Telomerase-independent stabilization of short telomeres in Trypanosoma brucei.Molecular and cellular biology · 2006Article
- The small chromosomes of Trypanosoma brucei involved in antigenic variation are constructed around repetitive palindromes.Genome research · 2004Article
- Repetitive elements in genomes of parasitic protozoa.Microbiology and molecular biology reviews : MMBR · 2003Review
- The sequence and analysis of Trypanosoma brucei chromosome II.Nucleic acids research · 2003Article
- The DNA sequence of chromosome I of an African trypanosome: gene content, chromosome organisation, recombination and polymorphism.Nucleic acids research · 2003Article
- Identification of a new ribosomal protection type of tetracycline resistance gene, tet(36), from swine manure pits.Applied and environmental microbiology · 2003Article
- A new, expressed multigene family containing a hot spot for insertion of retroelements is associated with polymorphic subtelomeric regions of Trypanosoma brucei.Eukaryotic cell · 2002Article
- Genetic analysis of phenotype in Trypanosoma brucei: a classical approach to potentially complex traits.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2002Article
- The polymorphic telomeres of the African Trypanosome trypanosoma brucei.Biochemical Society transactions · 2000Review
- Evolutionary genomics of Entamoeba.Research in microbiologyReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The chromosomes of many protozoans are polymorphic in size, but African trypanosomes contain diploid homologues which are exceptionally size-polymorphic. We present the first complete analysis of the structure of a Trypanosoma brucei megabase chromosome which reveals the concentration of repetitive sequence, non-random distribution of transposon-like elements, and a hemizygous variant surface glycoprotein gene expression site. Subsequent comparative analyses of size-polymorphic homologues show that the repetitive regions are highly polymorphic, as demonstrated in studies on the chromosomes of other protozoan parasites. We show that a large number of the transposon-like elements are located in these regions. However, although we have shown elsewhere that synteny is maintained in coding regions, homologous chromosomes may vary along their entire length. Thus, the variable chromosomal location of variant surface glycoprotein expression gene sites, the expansion and contraction of repetitive DNA, the number of putative transposons, sequence polymorphism at chromosome ends, and expansion and contraction within or between coding regions all contribute to huge chromosomal size polymorphisms in T brucei.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.