ArticleJournal of acquired immune deficiency syndromes (1999)1999
Insulin resistance in HIV protease inhibitor-associated diabetes.
Article in Journal of acquired immune deficiency syndromes (1999), 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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Who cites it
43 citing papers in PubMed, 129 citations in OpenAlex.
- Effects of once-daily darunavir/ritonavir versus atazanavir/ritonavir on insulin sensitivity in HIV-infected persons over 48 weeks: results of an exploratory substudy of METABOLIK, a phase 4, randomized trial.HIV clinical trials · 2016Trial
- Boosting dose ritonavir does not alter peripheral insulin sensitivity in healthy HIV-seronegative volunteers.Journal of acquired immune deficiency syndromes (1999) · 2010Trial
- Indinavir acutely inhibits insulin-stimulated glucose disposal in humans: a randomized, placebo-controlled study.AIDS (London, England) · 2002Trial
- Trial
- Prevalence of and factors associated with high atherogenic index among adults in Nairobi urban informal settlements: The AWI-Gen study.PLOS global public health · 2022Article
- A Step Closer to the "Fourth 90": A Practical Narrative Review of Diagnosis and Management of Nutritional Issues of People Living with HIV.Diagnostics (Basel, Switzerland) · 2021Review
- The Increase of HIV-1 Infection, Neurocognitive Impairment, and Type 2 Diabetes in The Rio Grande Valley.Current HIV research · 2019Review
- Insulin resistance and associated factors among HIV-infected patients in sub-Saharan Africa: a cross sectional study from Cameroon.Lipids in health and disease · 2017Article
- Brain GLUT4 Knockout Mice Have Impaired Glucose Tolerance, Decreased Insulin Sensitivity, and Impaired Hypoglycemic Counterregulation.Diabetes · 2017Article
- An inhibitor of HIV-1 protease modulates constitutive eIF2α dephosphorylation to trigger a specific integrated stress response.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Use Your Words Carefully: What Is a Chronic Disease?Frontiers in public health · 2016Article
- Hyperglycemia enhances kidney cell injury in HIVAN through down-regulation of vitamin D receptors.Cellular signalling · 2015Article
- Insulin resistance by homeostasis model assessment in HIV-infected patients on highly active antiretroviral therapy: cross-sectional study.Diabetology & metabolic syndrome · 2015Article
- Sequence-specific alterations of epitope production by HIV protease inhibitors.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- Relationships among HIV infection, metabolic risk factors, and left ventricular structure and function.AIDS research and human retroviruses · 2013Article
- Diabetes and HIV: current understanding and future perspectives.Current diabetes reports · 2013Review
- Effects of human immunodeficiency virus and metabolic complications on myocardial nutrient metabolism, blood flow, and oxygen consumption: a cross-sectional analysis.Cardiovascular diabetology · 2011Article
- Effects of the HIV protease inhibitor ritonavir on GLUT4 knock-out mice.The Journal of biological chemistry · 2010Article
- HIV-protease inhibitors suppress skeletal muscle fatty acid oxidation by reducing CD36 and CPT1 fatty acid transporters.Biochimica et biophysica acta · 2010Article
- Protease inhibitors used in the treatment of HIV+ induce beta-cell apoptosis via the mitochondrial pathway and compromise insulin secretion.American journal of physiology. Endocrinology and metabolism · 2009Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundFasting hyperglycemia has been associated with HIV protease inhibitor (PI) therapy.
objectiveTo determine whether absolute insulin deficiency or insulin resistance with relative insulin deficiency and an elevated body mass index (BMI) contribute to HIV PI-associated diabetes.
designCross-sectional evaluation. PATIENTS: 8 healthy seronegative men, 10 nondiabetic HIV-positive patients naive to PI, 15 nondiabetic HIV-positive patients receiving PI (BMI = 26 kg/m2), 6 nondiabetic HIV-positive patients receiving PI (BMI = 31 kg/m2), and 8 HIV-positive patients with diabetes receiving PI (BMI = 34 kg/m2). All patients on PI received indinavir. MEASUREMENTS: Fasting concentrations of glucoregulatory hormones. Direct effects of indinavir (20 microM) on rat pancreatic beta-cell function in vitro.
resultsIn hyperglycemic HIV-positive subjects, circulating concentrations of insulin, C-peptide, proinsulin, glucagon, and the proinsulin/insulin ratio were increased when compared with those of the other 4 groups (p < .05). Morning fasting serum cortisol concentrations were not different among the 5 groups. Glutamic acid decarboxylase (GAD) antibody titers were uncommon in all groups. High BMI was not always associated with diabetes. In vitro, indinavir did not inhibit proinsulin to insulin conversion or impair glucose-induced secretion of insulin and C-peptide from rat beta-cells.
conclusionsThe pathogenesis of HIV PI-associated diabetes involves peripheral insulin resistance with insulin deficiency relative to hyperglucagonemia and a high BMI. Pancreatic beta-cell function was not impaired by indinavir. HIV PI-associated diabetes mirrors that of non-insulin-dependent diabetes mellitus and impaired insulin action in the periphery.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.