ArticleThe Journal of physiology1999
Single-channel properties of BK-type calcium-activated potassium channels at a cholinergic presynaptic nerve terminal.
Article in The Journal of physiology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Evolution towards higher unitary conductance in mammals makes BK channels more efficient and precise.Communications biology · 2026Article
- Molecular basis for ligand-gating of the human GluD1 receptor.bioRxiv : the preprint server for biology · 2026Article
- Effects of emodepside on single-channel properties of Onchocerca volvulus SLO-1A (BK) potassium channels.Parasites & vectors · 2025Article
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- Large conductance voltage-and calcium-activated KFrontiers in pharmacology · 2024Review
- Regulation of Neurotransmitter Release by KAdvances in neurobiology · 2023Article
- Opening large-conductance potassium channels selectively induced cell death of triple-negative breast cancer.BMC cancer · 2020Article
- Distinct patterns of exocytosis elicited by CaPflugers Archiv : European journal of physiology · 2018Article
- Calcium-activated BKThe Journal of physiology · 2017Article
- Article
- Single-channel biophysical and pharmacological characterizations of native human large-conductance calcium-activated potassium channels in freshly isolated detrusor smooth muscle cells.Pflugers Archiv : European journal of physiology · 2013Article
- Properties of BK-type Ca(+) (+)-dependent K(+) channel currents in medial prefrontal cortex pyramidal neurons in rats of different ages.Frontiers in cellular neuroscience · 2013Article
- Automated parallel recordings of topologically identified single ion channels.Scientific reports · 2013Article
- Contribution of BK channels to action potential repolarisation at minimal cytosolic Ca2+ concentration in chromaffin cells.Pflugers Archiv : European journal of physiology · 2011Article
- Regulation of synaptic transmission by presynaptic CaMKII and BK channels.Molecular neurobiology · 2008Review
- Presynaptic Ca2+/calmodulin-dependent protein kinase II modulates neurotransmitter release by activating BK channels at Caenorhabditis elegans neuromuscular junction.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007Article
- Identification and functional characterization of ankyrin-repeat family protein ANKRA as a protein interacting with BKCa channel.Molecular biology of the cell · 2005Article
- Electrophysiological properties of BK channels in Xenopus motor nerve terminals.The Journal of physiology · 2004Article
- BK potassium channels control transmitter release at CA3-CA3 synapses in the rat hippocampus.The Journal of physiology · 2004Article
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
1. A high-conductance calcium-activated potassium channel (BK KCa) was characterized at a cholinergic presynaptic nerve terminal using the calyx synapse isolated from the chick ciliary ganglion. 2. The channel had a conductance of 210 pS in a 150 mM:150 mM K+ gradient, was highly selective for K+ over Na+, and was sensitive to block by external charybdotoxin or tetraethylammonium (TEA) and by internal Ba2+. At +60 mV it was activated by cytoplasmic calcium [Ca2+]i with a Kd of approximately 0.5 microM and a Hill coefficient of approximately 2.0. At 10 microM [Ca2+]i the channel was 50 % activated (V) at -8.0 mV with a voltage dependence (Boltzmann slope-factor) of 32.7 mV. The V values hyperpolarized with an increase in [Ca2+]i while the slope factors decreased. There were no overt differences in conductance or [Ca2+]i sensitivity between BK channels from the transmitter release face and the non-release face. 3. Open and closed times were fitted by two and three exponentials, respectively. The slow time constants were strongly affected by both [Ca2+]i and membrane potential changes. 4. In cell-attached patch recordings BK channel opening was enhanced by a prepulse permissive for calcium influx through the patch, suggesting that the channel can be activated by calcium ion influx through neighbouring calcium channels. 5. The properties of the presynaptic BK channel are well suited for rapid activation during the presynaptic depolarization and Ca2+ influx that are associated with transmitter release. This channel may play an important role in terminating release by rapid repolarization of the action potential.
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