ReviewLipids1999
Cellular fatty acid transport in heart and skeletal muscle as facilitated by proteins.
Review in Lipids, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 130 citations in OpenAlex.
- Neuroforensomics: metabolites as valuable biomarkers in cerebrospinal fluid of lethal traumatic brain injuries.Scientific reports · 2024Article
- Post-translational palmitoylation of metabolic proteins.Frontiers in physiology · 2023Review
- Cannabidiol Downregulates Myocardial de Novo Ceramide Synthesis Pathway in a Rat Model of High-Fat Diet-Induced Obesity.International journal of molecular sciences · 2022Article
- Potentiation of Ecstasy-induced hyperthermia and FAT/CD36 expression in chronically exercised animals.Temperature (Austin, Tex.) · 2016Article
- Modeling Fatty Acid Transfer from Artery to Cardiomyocyte.PLoS computational biology · 2015Article
- Prosteatotic genes are associated with unsaturated fat suppression of saturated fat-induced hepatic steatosis in C57BL/6 mice.Nutrition research (New York, N.Y.) · 2015Article
- Three Dimensional Structure Prediction of Fatty Acid Binding Site on Human Transmembrane Receptor CD36.Bioinformatics and biology insights · 2013Article
- The cardio-protective signaling and mechanisms of adiponectin.American journal of cardiovascular disease · 2012Article
- Identification of a possible role for atrial natriuretic peptide in MDMA-induced hyperthermia.Toxicology letters · 2011Article
- Association of genetic variants for FABP3 gene with back fat thickness and intramuscular fat content in pig.Molecular biology reports · 2011Article
- In obese Zucker rats, lipids accumulate in the heart despite normal mitochondrial content, morphology and long-chain fatty acid oxidation.The Journal of physiology · 2011Article
- The Randle cycle revisited: a new head for an old hat.American journal of physiology. Endocrinology and metabolism · 2009Review
- Cardiac substrate uptake and metabolism in obesity and type-2 diabetes: role of sarcolemmal substrate transporters.Molecular and cellular biochemistry · 2007Review
- Regulation of fatty acid transport: from transcriptional to posttranscriptional effects.Naunyn-Schmiedeberg's archives of pharmacology · 2006Article
- Purification, immunochemical quantification and localization in rat heart of putative fatty acid translocase (FAT/CD36).Molecular and cellular biochemistry · 2006Article
- Utilization of triacylglycerol-rich lipoproteins by the working rat heart: routes of uptake and metabolic fates.The Journal of physiology · 2004Article
- Effects of cAMP modulators on long-chain fatty-acid uptake and utilization by electrically stimulated rat cardiac myocytes.The Biochemical journal · 2002Article
- Sulfo-N-succinimidyl esters of long chain fatty acids specifically inhibit fatty acid translocase (FAT/CD36)-mediated cellular fatty acid uptake.Molecular and cellular biochemistry · 2002Review
- Regulation of fatty acid transport and membrane transporters in health and disease.Molecular and cellular biochemistry · 2002Review
- Giant membrane vesicles as a model to study cellular substrate uptake dissected from metabolism.Molecular and cellular biochemistry · 2002Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Despite the importance of long-chain fatty acids (FA) as fuels for heart and skeletal muscles, the mechanism of their cellular uptake has not yet been clarified. There is dispute as to whether FA are taken up by the muscle cells via passive diffusion and/or carrier-mediated transport. Kinetic studies of FA uptake by cardiac myocytes and the use of membrane protein-modifying agents have suggested the bulk of FA uptake is due to a protein component. Three membrane-associated FA-binding proteins were proposed to play a role in FA uptake, a 40-kDa plasma membrane FA-binding protein (FABPpm), an 88-kDa FA translocase (FAT/CD36), and a 60-kDa FA transport protein (FATP). In cardiac and skeletal myocytes the intracellular carrier for FA is cytoplasmic heart-type FA-binding protein (H-FABP), which likely transports FA from the sarcolemma to their intracellular sites of metabolism. A scenario is discussed in which FABPpm, FAT/CD36, and H-FABP, probably assisted by an albumin-binding protein, cooperate in the translocation of FA across the sarcolemma.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.