ArticleEnvironmental health perspectives1999
Radiation and mortality of workers at Oak Ridge National Laboratory: positive associations for doses received at older ages.
Article in Environmental health perspectives, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Systematic review and meta-analysis of circulatory disease from exposure to low-level ionizing radiation and estimates of potential population mortality risks.Environmental health perspectives · 2012Pooled it
- Review and meta-analysis of epidemiological associations between low/moderate doses of ionizing radiation and circulatory disease risks, and their possible mechanisms.Radiation and environmental biophysics · 2010Pooled it
- Radiation and circulatory disease.Mutation research. Reviews in mutation researchPooled it
- Radiation-associated circulatory disease mortality in a pooled analysis of 77,275 patients from the Massachusetts and Canadian tuberculosis fluoroscopy cohorts.Scientific reports · 2017Trial
- Updated findings on temporal variation in radiation-effects on cancer mortality in an international cohort of nuclear workers (INWORKS).European journal of epidemiology · 2024Article
- Ionizing radiation and solid cancer mortality among US nuclear facility workers.International journal of epidemiology · 2023Article
- Flexible Modeling of the Association Between Cumulative Exposure to Low-Dose Ionizing Radiation From Cardiac Procedures and Risk of Cancer in Adults With Congenital Heart Disease.American journal of epidemiology · 2019Article
- Low dose radiation and circulatory diseases: a brief narrative review.Cardio-oncology (London, England) · 2015Review
- A review of non-cancer effects, especially circulatory and ocular diseases.Radiation and environmental biophysics · 2013Review
- Integrative proteomic and microRNA analysis of primary human coronary artery endothelial cells exposed to low-dose gamma radiation.Radiation and environmental biophysics · 2013Article
- Article
- Cardiovascular changes in atherosclerotic ApoE-deficient mice exposed to Co60 (γ) radiation.PloS one · 2013Article
- Dose-responses from multi-model inference for the non-cancer disease mortality of atomic bomb survivors.Radiation and environmental biophysics · 2012Article
- Radiation-induced signaling results in mitochondrial impairment in mouse heart at 4 weeks after exposure to X-rays.PloS one · 2011Article
- Mortality patterns among Paducah Gaseous Diffusion Plant workers.Journal of occupational and environmental medicine · 2010Article
- A model of cardiovascular disease giving a plausible mechanism for the effect of fractionated low-dose ionizing radiation exposure.PLoS computational biology · 2009Article
- Investigating time patterns of variation in radiation cancer associations.Occupational and environmental medicine · 2005Article
- The risk linked to ionizing radiation: an alternative epidemiologic approach.Environmental health perspectives · 2001Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
We examined associations between low-level exposure to ionizing radiation and mortality among 14,095 workers hired at the Oak Ridge National Laboratory between 1943 and 1972. Workers at the facility were individually monitored for external exposure to ionizing radiation and have been followed through 1990 to ascertain cause of death information. Positive associations were observed between low-level exposure to external ionizing radiation and mortality. These associations were larger for doses received after 45 years of age, larger under longer lag assumptions, and primarily due to cancer causes of death. All cancer mortality was estimated to increase 4.98% [standard error (SE) = 1.5] per 10-mSv cumulative dose received after age 45 under a 10-year lag, and 7.31% (SE = 2.2) per 10-mSv cumulative dose received after age 45 under a 20-year lag. Associations between radiation dose and lung cancer were of similar magnitude to associations between radiation dose and all cancers except lung cancer. Nonmalignant respiratory disease exhibited a positive association with cumulative radiation dose received after age 45, whereas ischemic heart disease exhibited no association with radiation dose. These findings suggest increases in cancer mortality associated with low-level external exposure to ionizing radiation and potentially greater sensitivity to the carcinogenic effects of ionizing radiation with older ages at exposure.
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