Evidence map›Paper›PMID 10417209›Full record

ArticleInfection and immunity1999

Elevated chemokine concentrations in sera of human immunodeficiency virus (HIV)-seropositive and HIV-seronegative patients with tuberculosis: a possible role for mycobacterial lipoarabinomannan.

N P Juffermans, A Verbon, S J van Deventer, H van Deutekom, J T Belisle, M E Ellis, P Speelman, T van der Poll

Open access · bronzeAbstract read
In one paragraph

Article in Infection and immunity, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 88 citations in OpenAlex.

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  6. Positive Correlation between IP-10 and IFN-BioMed research international · 2017
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 3 countries.

N P JuffermansLaboratory of Experimental Internal Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands. N.Juffermans@amc.uva.nl
A Verbon
S J van Deventer
H van Deutekom
J T Belisle
M E Ellis
P Speelman
T van der Poll
Academic Medical Center · NLColorado State University · USInstitute of Experimental Endocrinology of the Slovak Academy of Sciences · SKGGD Amsterdam · NLUniversity of Amsterdam · NL

Funding

PHS HHS N01-A1-75320
6 · The paper itself

Abstract

Levels of interleukin 8 (IL-8), gamma interferon-inducible protein 10 (IP-10), monocyte chemoattractant protein 1 (MCP-1), and macrophage inflammatory protein 1beta (MIP-1beta) were elevated in patients with tuberculosis. IP-10 and MCP-1 levels were higher in human immunodeficiency virus (HIV)-seropositive patients than in HIV-seronegative patients with tuberculosis. Lipoarabinomannan induced IL-8, MCP-1, and MIP-1beta in vitro, which was partly inhibited by anti-tumor necrosis factor antibody.

Indexed as

Chemokine CCL2Chemokine CXCL10ChemokinesChemokines, CXCHIV SeronegativityHIV SeropositivityHumansInterleukin-8LipopolysaccharidesTuberculosisTumor Necrosis Factor-alphaChemokine CCL2Chemokine CXCL10ChemokinesChemokines, CXCInterleukin-8lipoarabinomannanLipopolysaccharidesTumor Necrosis Factor-alpha

Identifiers

PMID10417209
PMCPMC96742
OpenAlexW2146014199

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.