ArticleInfection and immunity1999
Comparative analysis of Legionella pneumophila and Legionella micdadei virulence traits.
Article in Infection and immunity, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 49 citations in OpenAlex.
- Undercover Agents of Infection: The Stealth Strategies of T4SS-Equipped Bacterial Pathogens.Toxins · 2021Review
- Development of a Fluorescent Tool for StudyingMicroorganisms · 2021Article
- Pneumonia and pulmonary abscess due toGerms · 2019Article
- Emerging respiratory infections: The infectious disease pathology of SARS, MERS, pandemic influenza, and Legionella.Seminars in diagnostic pathology · 2019Review
- Convective Mixing in Distal Pipes Exacerbates Legionella pneumophila Growth in Hot Water Plumbing.Pathogens (Basel, Switzerland) · 2016Article
- Review
- Mouse macrophages are permissive to motile Legionella species that fail to trigger pyroptosis.Infection and immunity · 2010Article
- Identification of Legionella pneumophila-specific genes by genomic subtractive hybridization with Legionella micdadei and identification of lpnE, a gene required for efficient host cell entry.Infection and immunity · 2006Article
- Temperature-regulated formation of mycelial mat-like biofilms by Legionella pneumophila.Applied and environmental microbiology · 2006Article
- Legionella pneumophila NudA Is a Nudix hydrolase and virulence factor.Infection and immunity · 2005Article
- Legionella pneumophila DotU and IcmF are required for stability of the Dot/Icm complex.Infection and immunity · 2004Article
- A specific genomic location within the icm/dot pathogenesis region of different Legionella species encodes functionally similar but nonhomologous virulence proteins.Infection and immunity · 2004Article
- Legionella dumoffii DjlA, a member of the DnaJ family, is required for intracellular growth.Infection and immunity · 2004Article
- Characterization of the icmH and icmF genes required for Legionella pneumophila intracellular growth, genes that are present in many bacteria associated with eukaryotic cells.Infection and immunity · 2004Article
- Legionella pneumophila feoAB promotes ferrous iron uptake and intracellular infection.Infection and immunity · 2002Article
- Population genetic structure of Legionella pneumophila inferred from RNA polymerase gene (rpoB) and DotA gene (dotA) sequences.Journal of bacteriology · 2002Article
- icmT is essential for pore formation-mediated egress of Legionella pneumophila from mammalian and protozoan cells.Infection and immunity · 2002Article
- Comparison of virulence of Legionella longbeachae strains in guinea pigs and U937 macrophage-like cells.Infection and immunity · 2001Article
- Identification of Legionella pneumophila rcp, a pagP-like gene that confers resistance to cationic antimicrobial peptides and promotes intracellular infection.Infection and immunity · 2001Article
- Identification and subcellular localization of the Legionella pneumophila IcmX protein: a factor essential for establishment of a replicative organelle in eukaryotic host cells.Infection and immunity · 2000Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
While the majority of Legionnaire's disease has been attributed to Legionella pneumophila, Legionella micdadei can cause a similar infection in immunocompromised people. Consistent with its epidemiological profile, the growth of L. micdadei in cultured macrophages is less robust than that of L. pneumophila. To identify those features of the Legionella spp. which are correlated to efficient growth in macrophages, two approaches were taken. First, a phenotypic analysis compared four clinical isolates of L. micdadei to one well-characterized strain of L. pneumophila. Seven traits previously correlated with the virulence of L. pneumophila were evaluated: infection and replication in cultured macrophages, evasion of phagosome-lysosome fusion, contact-dependent cytotoxicity, sodium sensitivity, osmotic resistance, and conjugal DNA transfer. By nearly every measure, L. micdadei appeared less virulent than L. pneumophila. The surprising exception was L. micdadei 31B, which evaded lysosomes and replicated in macrophages as efficiently as L. pneumophila, despite lacking both contact-dependent cytopathicity and regulated sodium sensitivity. Second, in an attempt to identify virulence factors genetically, an L. pneumophila genomic library was screened for clones which conferred robust intracellular growth on L. micdadei. No such loci were isolated, consistent with the multiple phenotypic differences observed for the two species. Apparently, L. pneumophila and L. micdadei use distinct strategies to colonize alveolar macrophages, causing Legionnaire's disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.