ArticleInfection and immunity1999
A murine model for infection with Burkholderia cepacia with sustained persistence in the spleen.
Article in Infection and immunity, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed, 18 citations in OpenAlex.
- Unique Presentations ofComparative medicine · 2023Article
- Characterization of the Burkholderia cenocepacia TonB Mutant as a Potential Live Attenuated Vaccine.Vaccines · 2017Article
- The art of persistence-the secrets to Burkholderia chronic infections.Pathogens and disease · 2016Review
- Review
- Role of excessive inflammatory response to Stenotrophomonas maltophilia lung infection in DBA/2 mice and implications for cystic fibrosis.Infection and immunity · 2010Article
- Burkholderia cenocepacia creates an intramacrophage replication niche in zebrafish embryos, followed by bacterial dissemination and establishment of systemic infection.Infection and immunity · 2010Article
- Differential modulation of Burkholderia cenocepacia virulence and energy metabolism by the quorum-sensing signal BDSF and its synthase.Journal of bacteriology · 2009Article
- Spontaneous septic arthritis caused by Burkholderia cepacia.The Iowa orthopaedic journal · 2006Article
- Colonial morphology of Burkholderia cepacia complex genomovar III: implications in exopolysaccharide production, pilus expression, and persistence in the mouse.Infection and immunity · 2003Article
- Differential persistence among genomovars of the Burkholderia cepacia complex in a murine model of pulmonary infection.Infection and immunity · 2002Article
- Correlation between an in vitro invasion assay and a murine model of Burkholderia cepacia lung infection.Infection and immunity · 2002Article
- Enhanced susceptibility to pulmonary infection with Burkholderia cepacia in Cftr(-/-) mice.Infection and immunity · 2001Article
- Outbreak of subclinical mastitis in a flock of dairy sheep associated with Burkholderia cepacia complex infection.Journal of clinical microbiology · 2001Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Burkholderia cepacia is an opportunistic pathogen that causes severe systemic infections in patients with chronic granulomatous disease (CGD) or with cystic fibrosis (CF), but its mechanisms of virulence are poorly understood. We developed a murine model of systemic infection in wild-type (WT) and gamma interferon knockout (GKO) BALB/c mice to facilitate dissection of components of pathogenicity and host defense. Both WT and GKO mice were susceptible to chronic splenic infection with B. cepacia, but not with Pseudomonas aeruginosa. B. cepacia strains from patients with CGD persisted longer than those from CF patients. C57BL/6 mice were the most susceptible murine strain; bacteria persisted in the spleen for 2 months. DBA/2, BALB/c, and A/J strains of mice were relatively resistant to infection. Certain strains of B. cepacia complex can persist in the murine spleen after systemic infection; this may provide clues to its virulence in compromised hosts, such as those with CGD and CF.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.