ArticleInfection and immunity1999
Thymic independence of adaptive immunity to the intracellular pathogen Shigella flexneri serotype 2a.
Article in Infection and immunity, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed.
- A multi-epitope protein vaccine encapsulated in alginate nanoparticles as a candidate vaccine against Shigella sonnei.Scientific reports · 2024Article
- Functional and Antigen-Specific Serum Antibody Levels as Correlates of Protection against Shigellosis in a Controlled Human Challenge Study.Clinical and vaccine immunology : CVI · 2017Article
- Intradermal delivery of Shigella IpaB and IpaD type III secretion proteins: kinetics of cell recruitment and antigen uptake, mucosal and systemic immunity, and protection across serotypes.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- Article
- Antigen-specific CD8(+) T cells fail to respond to Shigella flexneri.Infection and immunity · 2011Article
- Adaptive immune responses during Shigella dysenteriae type 1 infection: an in vitro stimulation with 57 kDa major antigenic OMP in the presence of anti-CD3 antibody.Molecular and cellular biochemistry · 2010Article
- Virulence, inflammatory potential, and adaptive immunity induced by Shigella flexneri msbB mutants.Infection and immunity · 2010Article
- Immunoproteome analysis of soluble and membrane proteins of Shigella flexneri 2457T.World journal of gastroenterology · 2006Article
- Complete genome sequence and comparative genomics of Shigella flexneri serotype 2a strain 2457T.Infection and immunity · 2003Article
- Complete DNA sequence and analysis of the large virulence plasmid of Shigella flexneri.Infection and immunity · 2001Article
- Periplasmic transit and disulfide bond formation of the autotransported Shigella protein IcsA.Journal of bacteriology · 2001Article
- The pathogenesis of Shigella flexneri infection: lessons from in vitro and in vivo studies.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2000Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Shigella flexneri is a facultative intracellular pathogen. While immunity to several intracellular pathogens is mediated by T lymphocytes, it is unknown whether cellular immune responses are important to adaptive immunity to S. flexneri. We show that vaccination with S. flexneri serotype 2a confers protection to mice that lack T lymphocytes or gamma interferon (IFN-gamma), specific depletion of T lymphocytes does not alter the protection, and adoptive transfer of splenocytes from vaccinated mice does not confer protection to naive mice. In contrast, vaccination conferred no protection to mice that lack B lymphocytes and adoptive transfer of immune sera conferred partial protection to naive mice. These data demonstrate that in the mouse bronchopulmonary model, adaptive immunity to S. flexneri 2a is an antibody-mediated, B-lymphocyte-dependent process and can be generated in the absence of T lymphocytes or IFN-gamma.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.