ArticleBrain pathology (Zurich, Switzerland)1999
High frequency of TP53 mutations in juvenile pilocytic astrocytomas indicates role of TP53 in the development of these tumors.
Article in Brain pathology (Zurich, Switzerland), 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.
- P53 codon 72 Arg/Pro polymorphism and glioma risk: an updated meta-analysis.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2013Pooled it
- Antisense-mediated splicing correction as a therapeutic approach for p53 K120R mutation.BMB reports · 2024Article
- Clinical, histopathological and molecular risk factors for recurrence of pilocytic astrocytomas: brainstem/spinal location, nestin expression and gain of 7q and 19 are associated with early tumor recurrence.Brain tumor pathology · 2023Article
- K120R mutation inactivates p53 by creating an aberrant splice site leading to nonsense-mediated mRNA decay.Oncogene · 2019Article
- TP53 codon 72 polymorphism may predict early tumour progression in paediatric pilocytic astrocytoma.Oncotarget · 2016Article
- Germline TP53 Mutations in Patients With Early-Onset Colorectal Cancer in the Colon Cancer Family Registry.JAMA oncology · 2015Article
- p53 Acetylation: Regulation and Consequences.Cancers · 2014Review
- Concomitant bifocal urothelial carcinoma and breast tumor: second primary cancer or metastatic spread to the breast?Case reports in oncological medicine · 2014Article
- The differential diagnosis of pilocytic astrocytoma with atypical features and malignant glioma: an analysis of 16 cases with emphasis on distinguishing molecular features.Journal of neuro-oncology · 2013Article
- The molecular biology of WHO grade I astrocytomas.Neuro-oncology · 2012Review
- Innate neural stem cell heterogeneity determines the patterning of glioma formation in children.Cancer cell · 2012Article
- MAPK pathway activation in pilocytic astrocytoma.Cellular and molecular life sciences : CMLS · 2012Review
- A study of histopathological spectrum and expression of Ki-67, TP53 in primary brain tumors of pediatric age group.Indian journal of medical and paediatric oncology : official journal of Indian Society of Medical & Paediatric Oncology · 2012Article
- Impact of morphology, MIB-1, p53 and MGMT on outcome in pilocytic astrocytomas.Brain pathology (Zurich, Switzerland) · 2010Article
- Association of molecular alterations, including BRAF, with biology and outcome in pilocytic astrocytomas.Acta neuropathologica · 2010Article
- The p53 family and programmed cell death.Oncogene · 2008Review
- High-resolution, dual-platform aCGH analysis reveals frequent HIPK2 amplification and increased expression in pilocytic astrocytomas.Oncogene · 2008Article
- Genomic deletions correlate with underexpression of novel candidate genes at six loci in pediatric pilocytic astrocytoma.Neoplasia (New York, N.Y.) · 2008Article
- Males absent on the first (MOF): from flies to humans.Oncogene · 2007Review
- Acetylation of the p53 DNA-binding domain regulates apoptosis induction.Molecular cell · 2006Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In adults, the TP53 tumor suppressor gene is frequently mutated in astrocytic brain tumors which is supposed to represent an early event in their development. In juvenile pilocytic and low-grade astrocytomas, however, TP53 mutations have until now been reported as rare, which has led to the suggestion that these tumors may follow a different molecular pathogenesis with an involvement of genes other than TP53. Our analysis of 20 pilocytic and two low-grade astrocytomas of childhood, based on a comprehensive denaturing gradient gel electrophoresis (DGGE) mutation detection assay of the entire coding region, including all splice site junctions of TP53, showed mutations considered as causative in 7 of the 20 (35%) pilocytic astrocytomas and in one of the two low-grade astrocytomas. Our finding is significantly different from the mutation frequency of 1.3% (2/155) previously reported for these tumor types. This may be attributed to the mutation detection system used, which also detects mutations occurring outside the evolutionary conserved region of TP53. Our results suggest that, contrary to the present notion, TP53 mutations may well play a role in the development of juvenile astrocytomas. Furthermore, no mutations were found in tumors of patients with progression of residual tumor after postoperative follow-up. This suggests that TP53 mutations may be associated with less aggressive forms of juvenile astrocytomas, analogous to the situation in adult astrocytomas.
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