ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience1999
Glutamate inhibits thalamic reticular neurons.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
What it found
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The trial behind it
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Who cites it
38 citing papers in PubMed, 102 citations in OpenAlex.
- A novel mechanism for short-term post-tetanic plasticity in thalamocortical neurons.Brain research · 2025Article
- Distinct firing responses to synthetic synaptic currents in the adult murine reticular and relay thalamus.Journal of neurophysiology · 2025Article
- Post cardiac arrest physical exercise mitigates cell death in the septal and thalamic nuclei and ameliorates contextual fear conditioning deficits in rats.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2023Article
- The role of thalamic group II mGlu receptors in health and disease.Neuronal signaling · 2022Review
- Lysergic acid diethylamide differentially modulates the reticular thalamus, mediodorsal thalamus, and infralimbic prefrontal cortex: An in vivo electrophysiology study in male mice.Journal of psychopharmacology (Oxford, England) · 2021Article
- Dynamic Metabolic Changes in the Human Thalamus at the Transition From Waking to Sleep - Insights From Simultaneous Functional MR Spectroscopy and Polysomnography.Frontiers in neuroscience · 2019Article
- Synergy of Glutamatergic and Cholinergic Modulation Induces Plateau Potentials in Hippocampal OLM Interneurons.Frontiers in cellular neuroscience · 2019Article
- Astrocytes modulate thalamic sensory processing via mGlu2 receptor activation.Neuropharmacology · 2017Article
- mGluR1 and mGluR5 Synergistically Control Cholinergic Synaptic Transmission in the Thalamic Reticular Nucleus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Depression of neuronal excitability and epileptic activities by group II metabotropic glutamate receptors in the medial entorhinal cortex.Hippocampus · 2015Article
- Activation of Group I and Group II Metabotropic Glutamate Receptors Causes LTD and LTP of Electrical Synapses in the Rat Thalamic Reticular Nucleus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Metabotropic glutamate receptor 5 shows different patterns of localization within the parallel visual pathways in macaque and squirrel monkeys.Eye and brain · 2014Article
- The function of metabotropic glutamate receptors in thalamus and cortex.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2014Review
- Modulation of short-term plasticity in the corticothalamic circuit by group III metabotropic glutamate receptors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Thalamic microcircuits: presynaptic dendrites form two feedforward inhibitory pathways in thalamus.Journal of neurophysiology · 2013Article
- Activation requirements for metabotropic glutamate receptors.Neuroscience letters · 2013Article
- GABAA , NMDA and mGlu2 receptors tonically regulate inhibition and excitation in the thalamic reticular nucleus.The European journal of neuroscience · 2013Article
- Activity-dependent regulation of retinogeniculate signaling by metabotropic glutamate receptors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Intrinsic modulators of auditory thalamocortical transmission.Hearing research · 2012Article
- Glutamatergic inhibition in sensory neocortex.Cerebral cortex (New York, N.Y. : 1991) · 2009Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Activation of metabotropic glutamate receptors (mGluRs) can result in long-lasting modulation of neuronal excitability. Multiple mGluR subtypes are localized within the rat thalamic reticular nucleus (TRN), and we have examined the effects of activating these different receptor subtypes on the excitability of these neurons using an in vitro slice preparation. Typical of most mGluR-sensitive preparations, the general mGluR agonist, (+/-)-1-aminocyclopentane-trans-1,3-dicarboxylic acid (ACPD) produced a robust, long-lasting excitatory response. Surprisingly, ACPD produced a membrane hyperpolarization in some neurons. Using selective mGluR agonists, we found that activation of group II mGluRs produces the hyperpolarization, whereas the depolarization is mediated by group I mGluRs. While the polarity of the postsynaptic response (hyperpolarization vs depolarization) was dependent on the mGluR subtype activated, both actions appear to result from modification of a linear K(+) conductance. The inhibitory action of Glutamate, via group II mGluRs, provides an avenue for a disinhibitory effect that could have interesting consequences upon a well-investigated, model neuronal circuit, turning its assumed functional role upside down.
Indexed as
Identifiers
10414998PMC6782814W2098560768What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.