ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience1999
Autoregulatory sequences are revealed by complex stability screening of the mouse brn-3.0 locus.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 38 citations in OpenAlex.
- Novel Variant Identified in the Enhancer Region of Host Transcription Factor, BRN3A, is a Significant Risk Factor for HPV-Induced Uterine Cervix Cancer.International journal of molecular and cellular medicine · 2022Article
- Substituting mouse transcription factor Pou4f2 with a sea urchin orthologue restores retinal ganglion cell development.Proceedings. Biological sciences · 2016Article
- Red nucleus and rubrospinal tract disorganization in the absence of Pou4f1.Frontiers in neuroanatomy · 2015Article
- Isl1 and Pou4f2 form a complex to regulate target genes in developing retinal ganglion cells.PloS one · 2014Article
- Molecular analysis of oncogenicity of the transcription factor, BRN3A, in cervical cancer cells.Journal of cancer research and clinical oncology · 2011Article
- EWS/ETS proteins promote expression and regulate function of the homeodomain transcription factor BRN3A.Oncogene · 2010Article
- Brn3a regulates neuronal subtype specification in the trigeminal ganglion by promoting Runx expression during sensory differentiation.Neural development · 2010Article
- Brn3a regulates the transition from neurogenesis to terminal differentiation and represses non-neural gene expression in the trigeminal ganglion.Developmental dynamics : an official publication of the American Association of Anatomists · 2009Article
- Missense mutations in POU4F3 cause autosomal dominant hearing impairment DFNA15 and affect subcellular localization and DNA binding.Human mutation · 2008Article
- Eomesodermin, a target gene of Pou4f2, is required for retinal ganglion cell and optic nerve development in the mouse.Development (Cambridge, England) · 2008Article
- Brn3a target gene recognition in embryonic sensory neurons.Developmental biology · 2007Article
- POU-domain factor Brn3a regulates both distinct and common programs of gene expression in the spinal and trigeminal sensory ganglia.Neural development · 2007Article
- Brn3a-expressing retinal ganglion cells project specifically to thalamocortical and collicular visual pathways.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2005Article
- A differentially autoregulated Pet-1 enhancer region is a critical target of the transcriptional cascade that governs serotonin neuron development.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2005Article
- Interaction of Brn3a and HIPK2 mediates transcriptional repression of sensory neuron survival.The Journal of cell biology · 2004Article
- Distinct promoter elements mediate the co-operative effect of Brn-3a and p53 on the p21 promoter and their antagonism on the Bax promoter.Nucleic acids research · 2002Article
- Brn3a is a transcriptional regulator of soma size, target field innervation and axon pathfinding of inner ear sensory neurons.Development (Cambridge, England) · 2001Article
- The Ath5 proneural genes function upstream of Brn3 POU domain transcription factor genes to promote retinal ganglion cell development.Proceedings of the National Academy of Sciences of the United States of America · 2001Article
- Defects in sensory axon growth precede neuronal death in Brn3a-deficient mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2001Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
The POU-IV or Brn-3 class of transcription factors exhibit conserved structure, DNA-binding properties, and expression in specific subclasses of neurons across widely diverged species. In the mouse CNS, Brn-3.0 expression characterizes specific neurons from neurogenesis through the life of the cell. This irreversible activation of expression suggests positive autoregulation. To search for cis-acting elements that could mediate autoregulation we used a novel method, complex stability screening, which we applied to rapidly identify functional Brn-3.0 recognition sites within a large genomic region encompassing the mouse brn-3.0 locus. This method is based on the observation that the kinetic stability of Brn-3.0 complexes with specific DNA sequences, as measured by their dissociation half-lives, is highly correlated with the ability of those sequences to mediate transcriptional activation by Brn-3.0. The principal Brn-3.0 autoregulatory region lies approximately 5 kb upstream from the Brn-3.0 transcription start site and contains multiple Brn-3.0-binding sites that strongly resemble the optimal binding site for this protein class. This region also mediates transactivation by the closely related protein Brn-3.2, suggesting a regulatory cascade of POU proteins in specific neurons in which Brn-3.2 expression precedes Brn-3.0.
Indexed as
Identifiers
10414983PMC6782789W1868833618What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.