ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience1999
Conformational ensembles: the role of neuropeptide structures in receptor binding.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Nitric oxide suppresses cilia activity in ctenophores.bioRxiv : the preprint server for biology · 2023Article
- Recording cilia activity in ctenophores: effects of nitric oxide and low molecular weight transmitters.Frontiers in neuroscience · 2023Article
- RTExtract: time-series NMR spectra quantification based on 3D surface ridge tracking.Bioinformatics (Oxford, England) · 2020Article
- Conformational investigation of the structure-activity relationship of GdFFD and its analogues on an achatin-like neuropeptide receptor of Aplysia californica involved in the feeding circuit.Physical chemistry chemical physics : PCCP · 2018Article
- Peptide identifications and false discovery rates using different mass spectrometry platforms.Talanta · 2018Article
- The neuropeptide complement of the marine annelid Platynereis dumerilii.BMC genomics · 2013Article
- Antibodies against conserved amidated neuropeptide epitopes enrich the comparative neurobiology toolbox.EvoDevo · 2012Article
- Multiple post-translational modifications affect heterologous protein synthesis.The Journal of biological chemistry · 2012Article
- Analysis of Endogenous D-Amino Acid-Containing Peptides in Metazoa.Bioanalytical reviews · 2009Article
- NMR analysis of Caenorhabditis elegans FLP-18 neuropeptides: implications for NPR-1 activation.Biochemistry · 2006Article
- Orphan G protein-coupled receptors MrgA1 and MrgC11 are distinctively activated by RF-amide-related peptides through the Galpha q/11 pathway.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- A statistical view of FMRFamide neuropeptide diversity.Molecular neurobiologyReview
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Authors and funding
3 authors.
Funding
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Abstract
Conformational properties of several similar FMRFamide-like neuropeptides from mollusks were investigated by nuclear magnetic resonance (NMR) spectroscopy. It was found that amino acid substitutions in the N-terminal variable regions of the peptides had dramatic effects on the populations of reverse turns in solution. The populations of turns, as measured by two independent NMR parameters, were found to be highly correlated (r(2) = 0.93 and 0. 82) with IC(50) values using receptor membrane preparations from Helix aspersa (Payza, 1987; Payza et al., 1989). These results suggest that the amount of turn in the free peptide can influence the receptor binding affinities of that peptide. On the basis of these observations, a model was developed in which only a single species from a conformational ensemble of an unbound peptide will bind to a particular receptor. Thus, the conformational ensemble reduces the effective concentration of a particular peptide with respect to a particular receptor.
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Identifiers
10414961PMC6782823What OpenQuestion holds
Registered trials
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