ArticleProceedings of the National Academy of Sciences of the United States of America1999
One lyn molecule is sufficient to initiate phosphorylation of aggregated high-affinity IgE receptors.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
12 citing papers in PubMed, 35 citations in OpenAlex.
- Spatial requirements for ITAM signaling in an intracellular natural killer cell model membrane.Biochimica et biophysica acta. General subjects · 2022Article
- How the Discovery of the CD4/CD8-p56Frontiers in cell and developmental biology · 2021Review
- IgE-dependent signaling as a therapeutic target for allergies.Trends in pharmacological sciences · 2012Review
- A mechanistic model of early FcεRI signaling: lipid rafts and the question of protection from dephosphorylation.PloS one · 2012Article
- Adapters in the organization of mast cell signaling.Immunological reviews · 2009Review
- A mechanism for SRC kinase-dependent signaling by noncatalytic receptors.Biochemistry · 2008Review
- Cholesterol deficiency in a mouse model of Smith-Lemli-Opitz syndrome reveals increased mast cell responsiveness.The Journal of experimental medicine · 2006Article
- Rethinking the role of Src family protein tyrosine kinases in the allergic response: new insights on the functional coupling of the high affinity IgE receptor.Immunologic research · 2004Review
- Dynamic, yet structured: The cell membrane three decades after the Singer-Nicolson model.Proceedings of the National Academy of Sciences of the United States of America · 2003Review
- Unexpected signals in a system subject to kinetic proofreading.Proceedings of the National Academy of Sciences of the United States of America · 2001Article
- Kinetic proofreading models for cell signaling predict ways to escape kinetic proofreading.Proceedings of the National Academy of Sciences of the United States of America · 2001Article
- Spatial Stochastic Model of the Pre-B Cell Receptor.IEEE/ACM transactions on computational biology and bioinformaticsArticle
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
In response to antigenic stimuli, the multisubunit immune recognition receptors become aggregated and then phosphorylated on their cytoplasmic tyrosines. For the clonotypic receptors of B and T cells and for Fc receptors such as the high-affinity receptor for IgE (FcepsilonRI), a Src family kinase initiates this phosphorylation. We ask whether aggregation of the initiating kinase itself is required for signal transduction or whether, alternatively, a single associated kinase molecule can phosphorylate the receptors in an aggregate. We formulate the alternative molecular mechanisms mathematically and compare predictions with experimental findings on FcepsilonRI-bearing cells expressing varying amounts of the transfected Src family kinase Lyn. The data are consistent with the requirement of only a single Lyn molecule per FcepsilonRI aggregate to initiate signaling and are inconsistent with a mechanism requiring more than one Lyn molecule.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.