ArticleMolecular and cellular biology1999
Dual requirement for the EcR/USP nuclear receptor and the dGATAb factor in an ecdysone response in Drosophila melanogaster.
Article in Molecular and cellular biology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 40 citations in OpenAlex.
- Long-range repression by ecdysone receptor on complex enhancers of the insulin receptor gene.Fly · 2023Article
- Long-range repression by ecdysone receptor on complex enhancers of the insulin receptor gene.bioRxiv : the preprint server for biology · 2023Article
- Anatomy and evolution of a DNA replication origin.Chromosoma · 2021Article
- Article
- Syntax compensates for poor binding sites to encode tissue specificity of developmental enhancers.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- A view through a chromatin loop: insights into the ecdysone activation of early genes in Drosophila.Nucleic acids research · 2014Article
- The histone H3 acetylase dGcn5 is a key player in Drosophila melanogaster metamorphosis.Molecular and cellular biology · 2005Article
- Conditional expression in the malaria mosquito Anopheles stephensi with Tet-On and Tet-Off systems.Genetics · 2004Article
- Ecdysone receptor directly binds the promoter of the Drosophila caspase dronc, regulating its expression in specific tissues.The Journal of cell biology · 2004Article
- Absence of transitive and systemic pathways allows cell-specific and isoform-specific RNAi in Drosophila.RNA (New York, N.Y.) · 2003Article
- Two isoforms of Serpent containing either one or two GATA zinc fingers have different roles in Drosophila haematopoiesis.The EMBO journal · 2002Article
- Critical evaluation of the role of the Toll-like receptor 18-Wheeler in the host defense of Drosophila.EMBO reports · 2002Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The EcR/USP nuclear receptor controls Drosophila metamorphosis by activating complex cascades of gene transcription in response to pulses of the steroid hormone ecdysone at the end of larval development. Ecdysone release provides a ubiquitous signal for the activation of the receptor, but a number of its target genes are induced in a tissue- and stage-specific manner. Little is known about the molecular mechanisms involved in this developmental modulation of the EcR/USP-mediated pathway. Fbp1 is a good model of primary ecdysone response gene expressed in the fat body for addressing this question. We show here that the dGATAb factor binds to three target sites flanking an EcR/USP binding site in a 70-bp enhancer that controls the tissue and stage specificity of Fbp1 transcription. We demonstrate that one of these sites and proper expression of dGATAb are required for specific activation of the enhancer in the fat body. In addition, we provide further evidence that EcR/USP plays an essential role as a hormonal timer. Our study provides a striking example of the integration of molecular pathways at the level of a tissue-specific hormone response unit.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.