ArticleBritish journal of cancer1999
Loss of heterozygosity and microsatellite instability in hepatocellular carcinoma in Taiwan.
Article in British journal of cancer, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 64 citations in OpenAlex.
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- A machine learning-based SNP-set analysis approach for identifying disease-associated susceptibility loci.Scientific reports · 2022Article
- Molecular Noninvasive Diagnosis of Hepatocellular Carcinoma Using Microsatellite Instability.Asian Pacific journal of cancer prevention : APJCP · 2021Article
- BRIT1 dysfunction confers synergistic inhibition of hepatocellular carcinoma by targeting poly (ADP-ribose) polymerases and PI3K.American journal of cancer research · 2020Article
- Mutations inJournal of Cancer · 2018Article
- Silencing NKD2 by promoter region hypermethylation promotes gastric cancer invasion and metastasis by up-regulating SOX18 in human gastric cancer.Oncotarget · 2015Article
- Epigenetic silencing of NKD2, a major component of Wnt signaling, promotes breast cancer growth.Oncotarget · 2015Article
- TUSC1, a putative tumor suppressor gene, reduces tumor cell growth in vitro and tumor growth in vivo.PloS one · 2013Article
- Allelic loss on chromosome 5q34 is associated with poor prognosis in hepatocellular carcinoma.Journal of cancer research and clinical oncology · 2008Article
- Clinicopathological significance of loss of heterozygosity and microsatellite instability in hepatocellular carcinoma in China.World journal of gastroenterology · 2005Article
- Article
- Inactivation of p57KIP2 by regional promoter hypermethylation and histone deacetylation in human tumors.Oncogene · 2002Article
- Genetic mechanisms of hepatocarcinogenesis.Oncogene · 2002Review
- Genetic and immunohistochemical analysis of pancreatic acinar cell carcinoma: frequent allelic loss on chromosome 11p and alterations in the APC/beta-catenin pathway.The American journal of pathology · 2002Article
- Recurrent allelic deletions at mouse chromosomes 4 and 14 in Myc-induced liver tumors.Oncogene · 2002Article
- Comparative genomic hybridization reveals population-based genetic alterations in hepatoblastomas.British journal of cancer · 2000Article
Corrections and comments
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Authors and funding
13 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Elucidation of the basic genetic changes of human hepatocellular carcinoma is important for the understanding and treatment of this cancer. We used microsatellite polymorphism markers to study 30 cases of hepatocellular carcinoma (34 tumours) on all human chromosomes. DNA from 34 pairs of hepatocellular carcinomas and corresponding non-tumour parts was prepared. Loss of heterozygosity (LOH) and microsatellite instability on 23 chromosomes were investigated by 231 sets of microsatellite markers. More than 20% LOH was shown for loci on 16q (47.1%), 13q (32.4%), 17p (32.4%), 5q (26.5%), 11p (23.5%) and 9p (20.6%). The commonly affected regions were mapped to 16q12.1, 16q12.2, 16q24, 13q12.1-32, 17p13, 5q32, 5q34, 5q3, 11p15, 11q23-24 and 9p21. Hepatitis B virus carriers had a significantly higher frequency of LOH on chromosomes 5q, 11p and 16q. Furthermore, larger tumour size tended to have higher frequency of LOH at D16S409 locus (16q12.1). Microsatellte instability was only found in 12 of 231 markers and the frequency is very low. These data suggest that the chromosomes 16q, 13q, 17p, 5q, 11p and 9p might participate in hepatocarcinogenesis. However, microsatellite instability might play little role in the development of this cancer in Taiwan.
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