ArticleBritish journal of cancer1999
Absence of mutation of the p73 gene localized at chromosome 1p36.3 in hepatocellular carcinoma.
Article in British journal of cancer, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 37 citations in OpenAlex.
- E2F transcription factors and digestive system malignancies: how much do we know?World journal of gastroenterology · 2014Article
- Gain of miR-151 on chromosome 8q24.3 facilitates tumour cell migration and spreading through downregulating RhoGDIA.Nature cell biology · 2010Article
- Rare allelic imbalances, but no mutations of the PRDX1 gene in human hepatocellular carcinomas.Journal of clinical pathology · 2005Article
- p73, a sophisticated p53 family member in the cancer world.Cancer science · 2005Review
- Article
- Primary adenocarcinomas of lower esophagus, esophagogastric junction and gastric cardia: in special reference to China.World journal of gastroenterology · 2003Review
- p73beta inhibits transcriptional activities of enhancer I and X promoter in hepatitis B virus more efficiently than p73alpha.World journal of gastroenterology · 2002Article
- p73 overexpression and nuclear accumulation in hepatitis C virus-associated hepatocellular carcinoma.Digestive diseases and sciences · 2002Article
- Acquired expression of transcriptionally active p73 in hepatocellular carcinoma cells.Oncogene · 2001Article
- Mutation analysis of P73 and TP53 in Merkel cell carcinoma.British journal of cancer · 2000Article
- p73 at chromosome 1p36.3 is lost in advanced stage neuroblastoma but its mutation is infrequent.Oncogene · 1999Article
- The human p73 promoter: characterization and identification of functional E2F binding sites.Neoplasia (New York, N.Y.)Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Accumulating evidence has demonstrated that aberration of the p53 tumour-suppressor gene is one of the pivotal genetic events in hepatocellular carcinogenesis. Recent reports suggest that the product of hepatitis B virus (HBV) interacts with p53 and that the hepatitis C virus (HCV) core protein reduces p53 expression. A novel p73 gene, which is related to p53, has recently been identified and mapped to chromosome 1p36.3, which is a locus of multiple tumour-suppressor genes for many cancers, including hepatocellular carcinoma (HCC) and neuroblastoma. Here, we investigated mRNA expression, allelotype and mutation of p73 in 48 HCCs obtained from untreated patients. Reverse transcriptase polymerase chain reaction (RT-PCR) revealed that p73 mRNA was expressed ubiquitously at low levels in all the tumour tissues, as well as in the adjacent normal liver tissues. The frequency of p73 loss of heterozygosity was observed in 20% of HCCs, but PCR-single strand conformation polymorphism (SSCP) analysis showed no mutations in the 48 tumours except for three types of polymorphisms. These results suggest that p73 may play a role in hepatocellular carcinogenesis in a different manner from a Knudson two-hit model. The regulatory mechanism of interaction between p73 and hepatitis viruses remains to be determined.
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