ArticleBritish journal of cancer1999
E-cadherin gene mutations are rare in adenocarcinomas of the oesophagus.
Article in British journal of cancer, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 47 citations in OpenAlex.
- Article
- OTUB1 promotes metastasis and serves as a marker of poor prognosis in colorectal cancer.Molecular cancer · 2014Article
- Exome and whole-genome sequencing of esophageal adenocarcinoma identifies recurrent driver events and mutational complexity.Nature genetics · 2013Article
- Involvement of members of the cadherin superfamily in cancer.Cold Spring Harbor perspectives in biology · 2009Review
- Overexpression of Slug is associated with malignant progression of esophageal adenocarcinoma.World journal of gastroenterology · 2008Article
- Molecular changes in the progression of Barrett's oesophagus.Postgraduate medical journal · 2007Review
- Loss of heterozygosity testing using real-time PCR analysis of single nucleotide polymorphisms.Journal of cancer research and clinical oncology · 2006Article
- Expression of e-cadherin and beta-catenin in human esophageal squamous cell carcinoma: relationships with prognosis.World journal of gastroenterology · 2003Article
- Molecular biology of Barrett's adenocarcinoma.Annals of surgery · 2001Review
- Alterations of E-cadherin and beta-catenin in gastric cancer.BMC cancer · 2001Article
- Human oesophageal adenocarcinoma cell lines JROECL 47 and JROECL 50 are admixtures of the human colon carcinoma cell line HCT 116.British journal of cancer · 2000Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Reduced expression of E-cadherin, a cell-cell adhesion molecule, is observed in oesophageal adenocarcinomas and correlates with less favourable pathological parameters and survival. To determine if genetic events lead to reduced E-cadherin expression in these patients, we screened all 16 exons of the E-cadherin gene for mutations with the polymerase chain reaction single-strand conformation polymorphism analysis (PCR-SSCP) technique in 49 resection specimens, including four loco-regional lymph node metastases, four established cell lines and four xenografts. Fifteen exon-spanning primer pairs were used, and in nine amplicons aberrant bands were detected. Sequencing of the amplicons revealed a one base-pair deletion (codon 120; exon 3) in cell lines JROECL 47 and JROECL 50 leading to a premature downstream stop codon. Polymorphisms were identified for amplicons 1, 4/5, 11, 12, 13, 14 and 16 corresponding with data from the literature. Three new polymorphisms were detected for amplicons 2, 3 and 4/5. Loss of heterozygosity (LOH) of the E-cadherin locus on 16q22.1 was examined with four polymorphic markers. LOH was found in 31 of the 48 informative cases (65%). These results show that, despite the frequent LOH of the E-cadherin locus, mutations in the E-cadherin gene are rare events and can not be held responsible for down-regulation of E-cadherin observed in the majority of adenocarcinomas of the oesophagus.
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