ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience1999
Addiction-prone Lewis but not Fischer rats develop compulsive running that coincides with downregulation of nerve growth factor inducible-B and neuron-derived orphan receptor 1.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 57 citations in OpenAlex.
- Astrocytic glutamate transporter 1 (GLT1) deficient mice exhibit repetitive behaviors.Behavioural brain research · 2021Article
- What can be learnt from wheel-running by wild mice, and how can we identify when wheel-running is pathological?Proceedings. Biological sciences · 2016Article
- Nur transcription factors in stress and addiction.Frontiers in molecular neuroscience · 2013Review
- Hyperactive hypothalamus, motivated and non-distractible chronic overeating in ADAR2 transgenic mice.Genes, brain, and behavior · 2013Article
- The use of a running wheel to measure activity in rodents: relationship to energy balance, general activity, and reward.Neuroscience and biobehavioral reviews · 2012Review
- Chronic forced exercise during adolescence decreases cocaine conditioned place preference in Lewis rats.Behavioural brain research · 2010Article
- Wheel running, voluntary ethanol consumption, and hedonic substitution.Alcohol (Fayetteville, N.Y.) · 2008Article
- Higher locomotor response to cocaine in female (vs. male) rats selectively bred for high (HiS) and low (LoS) saccharin intake.Pharmacology, biochemistry, and behavior · 2007Article
- Running is rewarding and antidepressive.Physiology & behavior · 2007Review
- Nur77 and retinoid X receptors: crucial factors in dopamine-related neuroadaptation.Trends in neurosciences · 2007Review
- Delta FosB regulates wheel running.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2002Article
- The aetiology of idiopathic Parkinson's disease.Molecular pathology : MP · 2001Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have examined the effects of chronic voluntary running for 30 d on the levels of nerve growth factor inducilble-B (NGFI-B) and neuron-derived orphan receptor 1 (NOR1) mRNAs in Fischer and Lewis rats. The aim was to compare the addiction-prone Lewis rat strain to the Fischer strain in a plausible model for natural reward. The Lewis strain ran markedly more than the Fischer strain, as indicated by the length of running per day when given free access to running wheels. Both strains progressively increased their amount of daily running. By day 14, Lewis rats had reached a maximal level corresponding to 10 km/d, which slowly decreased to approximately 8 km/d. Fischer rats ran considerably less, averaging approximately 1. 5 km/d by day 30. After 30 d of running, levels of mRNA encoding NGFI-B and Nor1 were decreased in cerebral cortex in Lewis but not Fischer rats. The downregulation of NGFI-B mRNA in Lewis rats could not be attenuated by the opioid receptor antagonist naloxone. Instead, naloxone by itself downregulated NGFI-B in striatum and cerebral cortex in both strains. In contrast, naloxone had no effect on Nor1 mRNA levels, although the running-induced downregulation of Nor1 was, in most cases, attenuated by naloxone. Data from the present study suggest that the same genetic factors contributing to the drug addiction-prone behavior of Lewis rats also control the excessive running behavior and that this coincides with downregulation of transcription factors of the NGFI-B family.
Indexed as
Identifiers
10407052PMC6783058W2118359129What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.