ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience1999
Molecular evidence for the early specification of presumptive functional domains in the embryonic primate cerebral cortex.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 129 citations in OpenAlex.
- Sensory modality-specific wiring of thalamocortical circuits.Nature reviews. Neuroscience · 2025Review
- A twisted visual field map in the primate dorsomedial cortex predicted by topographic continuity.Science advances · 2020Article
- Subtype-Specific Genes that Characterize Subpopulations of Callosal Projection Neurons in Mouse Identify Molecularly Homologous Populations in Macaque Cortex.Cerebral cortex (New York, N.Y. : 1991) · 2017Article
- EphA5 and EphA6: regulation of neuronal and spine morphology.Cell & bioscience · 2016Article
- The relevance of human fetal subplate zone for developmental neuropathology of neuronal migration disorders and cortical dysplasia.CNS neuroscience & therapeutics · 2015Review
- The effects of lifelong blindness on murine neuroanatomy and gene expression.Frontiers in aging neuroscience · 2015Article
- Mapping arealisation of the visual cortex of non-primate species: lessons for development and evolution.Frontiers in neural circuits · 2014Review
- 'Til Eph do us part': intercellular signaling via Eph receptors and ephrin ligands guides cerebral cortical development from birth through maturation.Cerebral cortex (New York, N.Y. : 1991) · 2013Review
- Bilateral enucleation alters gene expression and intraneocortical connections in the mouse.Neural development · 2012Article
- Neuronal migration disorders in microcephalic osteodysplastic primordial dwarfism type I/III.Acta neuropathologica · 2011Article
- TBR1 directly represses Fezf2 to control the laminar origin and development of the corticospinal tract.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- The clinical-basic interface in defining pathogenesis in disorders of neurodevelopmental origin.Neuron · 2010Article
- Article
- Genomic characterisation of a Fgf-regulated gradient-based neocortical protomap.Development (Cambridge, England) · 2005Article
- Grading the thalamus: how can an 'Eph' be excellent?Thalamus & related systems · 2005Article
- Fibroblast growth factor 8 regulates neocortical guidance of area-specific thalamic innervation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2005Article
- Ephrin-A2 reverse signaling negatively regulates neural progenitor proliferation and neurogenesis.Genes & development · 2005Article
- Neurons of layer I and their significance in the embryogenesis of the neocortex.Neuroscience and behavioral physiology · 2004Review
- Corpus callosum deficiency in transgenic mice expressing a truncated ephrin-A receptor.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2003Article
- The representation of retinal blood vessels in primate striate cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2003Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To identify molecules that may play a role in the initiation of cerebral cortical area formation, we examined the expression of the Eph receptors and their ligands, the ephrins, during primate corticogenesis. We selected the macaque monkey neocortex because of its clear areal subdivisions, large surface area, protracted development (gestation = 165 d), and similarity to the human brain. In situ hybridizations, performed at early [embryonic day 65 (E65)], middle (E80), and late (E95) stages of cortical development, revealed that EphA system family members are expressed in distinct gradients and laminar and areal domains in the embryonic neocortex. Indeed, several regionally restricted molecular patterns are already apparent within the cortical plate at E65, before the formation of thalamocortical connections, suggesting that the initial expression of some EphA system members is regulated by programs intrinsic to cortical cells. For example, EphA3, EphA6, and EphA7 are all selectively expressed within the presumptive visual cortex. However, although EphA6 and EphA7 are present throughout this region, EphA3 is only expressed in the prospective extrastriate cortex, suggesting that cortical cells harbor functional biases that may influence the formation of appropriate synaptic connections. Although several patterns of early gene expression are stable (e.g., EphA3, EphA4, and EphA6), others change as development proceeds (e.g., EphA5, EphA7, ephrin-A2, ephrin-A3, and ephrin-A5), perhaps responding to extrinsic cues. Thus, at E95, after connections between the cortical plate and thalamus have formed, receptor subtypes EphA3, EphA5, EphA6, and EphA7 and the ligand ephrin-A5 are expressed in posterior regions, whereas EphA4 and ephrin-A2 and ephrin-A3 are either uniformly distributed or anteriorly biased. Taken together, our results demonstrate molecular distinctions among cells of the embryonic primate neocortex, revealing hitherto unrecognized compartmentalization early in corticogenesis.
Indexed as
Identifiers
10407035PMC6783094W1946674388What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.