ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience1999
Subcellular localization of full-length and truncated Trk receptor isoforms in polarized neurons and epithelial cells.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 55 citations in OpenAlex.
- Primary neurons lacking the SNAREs vti1a and vti1b show altered neuronal development.Neural development · 2022Article
- The 3' UTRs of Brain-Derived Neurotrophic Factor Transcripts Differentially Regulate the Dendritic Arbor.Frontiers in cellular neuroscience · 2018Article
- Regulation of actions and habits by ventral hippocampal trkB and adolescent corticosteroid exposure.PLoS biology · 2017Article
- Melanocortin 3 receptor has a 5' exon that directs translation of apically localized protein from the second in-frame ATG.Molecular endocrinology (Baltimore, Md.) · 2014Article
- Differential regulation of BDNF, synaptic plasticity and sprouting in the hippocampal mossy fiber pathway of male and female rats.Neuropharmacology · 2014Article
- BDNF-dependent recycling facilitates TrkB translocation to postsynaptic density during LTP via a Rab11-dependent pathway.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- A role for the tyrosine kinase ACK1 in neurotrophin signaling and neuronal extension and branching.Cell death & disease · 2013Article
- Essential role of Hrs in endocytic recycling of full-length TrkB receptor but not its isoform TrkB.T1.The Journal of biological chemistry · 2009Article
- Differential activation of Rac1 and RhoA in neuroblastoma cell fractions.Neuroscience letters · 2009Article
- Role of accumbens BDNF and TrkB in cocaine-induced psychomotor sensitization, conditioned-place preference, and reinstatement in rats.Psychopharmacology · 2008Article
- A comparative computer simulation of dendritic morphology.PLoS computational biology · 2008Article
- TrkB gene transfer does not alter hippocampal neuronal loss and cognitive deficits following traumatic brain injury in mice.Restorative neurology and neuroscience · 2008Article
- The dynamic distribution of TrkB receptors before, during, and after synapse formation between cortical neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006Article
- Long-term adeno-associated viral vector-mediated expression of truncated TrkB in the adult rat facial nucleus results in motor neuron degeneration.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006Article
- What is the biological significance of BDNF mRNA targeting in the dendrites? Clues from epilepsy and cortical development.Molecular neurobiology · 2006Review
- Local diameter fully constrains dendritic size in basal but not apical trees of CA1 pyramidal neurons.Journal of computational neuroscience · 2005Article
- The Rab5 effector Rabankyrin-5 regulates and coordinates different endocytic mechanisms.PLoS biology · 2004Article
- A novel sorting motif in the glutamate transporter excitatory amino acid transporter 3 directs its targeting in Madin-Darby canine kidney cells and hippocampal neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2002Article
- Anterograde axonal transport, transcytosis, and recycling of neurotrophic factors: the concept of trophic currencies in neural networks.Molecular neurobiologyReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neurotrophins affect neuronal development and plasticity via spatially localized effects, yet little is known about the subcellular distribution of the Trk neurotrophin receptors and the impact of this distribution on neurotrophin action. To address this, we examined the subcellular location of full-length TrkB and TrkC tyrosine kinase receptors and truncated TrkB isoforms after transfection of Madin-Darby canine kidney (MDCK) cells, dissociated primary hippocampal neurons, and cortical neurons within intact brain slices. Myc-, herpes virus glycoprotein (HVG)-, or FLAG-derived epitope-tagged receptor isoforms were created to allow their unambiguous identification and localization after transfection. All tagged receptors were appropriately synthesized, and full-length myc-TrkB and myc-TrkC mediated appropriate neurotrophin-signaling events. We found that full-length TrkB receptors were excluded from the apical domain of MDCK cells but that TrkC receptors were present in both apical and basolateral domains. Full-length TrkB and TrkC were found throughout transfected primary cultured hippocampal neurons and transfected neurons in neocortical brain slices and showed no evidence of vectorial sorting. Truncated forms of TrkB were also homogeneously distributed in MDCK cells, dissociated hippocampal neurons, and cortical neurons within slice preparations. Levels of full-length and truncated TrkB were examined in postsynaptic densities; both receptor isoforms were present but only moderately enriched in these structures. Together, these findings suggest that Trk receptors are uniformly distributed in both axonal and dendritic compartments and that local neurotrophin responses are controlled by other mechanisms.
Indexed as
Identifiers
10407023PMC6783076W1677823991What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.