ArticleBMJ (Clinical research ed.)1999
Does zygosity influence the metabolic profile of twins? A population based cross sectional study.
Article in BMJ (Clinical research ed.), 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 58 citations in OpenAlex.
- Article
- Carboxylesterase 1 gene duplication and mRNA expression in adipose tissue are linked to obesity and metabolic function.PloS one · 2013Article
- Article
- Article
- No evidence of a higher 10 year period prevalence of diabetes among 77,885 twins compared with 215,264 singletons from the Danish birth cohorts 1910-1989.Diabetologia · 2011Article
- Fetal origins of adult disease.Current problems in pediatric and adolescent health care · 2011Review
- Regulation and function of FTO mRNA expression in human skeletal muscle and subcutaneous adipose tissue.Diabetes · 2009Article
- Genetic and environmental contributions to phenotypic components of metabolic syndrome: a population-based twin study.Obesity (Silver Spring, Md.) · 2009Article
- Increased risk of type 2 diabetes in elderly twins.Diabetes · 2009Article
- The late effects of fetal growth patterns.Archives of disease in childhood. Fetal and neonatal edition · 2006Review
- Plasma cytokine levels in young and elderly twins: genes versus environment and relation to in vivo insulin action.Diabetologia · 2006Article
- The effect of in-utero undernutrition on the insulin resistance syndrome.Current diabetes reports · 2002Review
- Reading journals and monitoring the published work.Journal of the Royal Society of Medicine · 2000Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo study the influence of zygosity on the metabolic variables involved in the pathophysiology of type 2 diabetes.
designPopulation based cross sectional study.
settingOdense University Hospital, Denmark.
participants125 monozygotic twin pairs and 178 dizygotic twin pairs of the same sex born between 1921 and 1940.
main outcome measuresClinical characteristics of monozygotic and dizygotic twins with or without a family history of type 2 diabetes.
resultsAbsolute prevalences of type 2 diabetes and impaired glucose tolerance according to the World Health Organisation criteria were similar in both the monozygotic and the dizygotic twins as were measurements of height, weight, body mass index, waist to hip ratio, and fasting plasma glucose and insulin concentrations. During the oral glucose tolerance test, monozygotic twins had a higher incremental plasma insulin area under the curve than dizygotic twins (10.05 (SD 0.68) v 9.89 (0.72) pmol/lxminutes, P<0.01) indicating insulin resistance. In twins with normal glucose tolerance and without first degree relatives or co-twins with type 2 diabetes or impaired glucose tolerance, both the glucose and insulin areas under the curve were higher among monozygotic twins (glucose 214.4 (88.3) v 189.8 (78.4) mmol/lxminutes, P<0.05; insulin 20 040 (14 865-32 554) v 17 625 (12 330-23 640) pmol/lxminutes, P=0.08).
conclusionZygosity influences both plasma glucose and plasma insulin concentrations during an oral glucose tolerance test. This supports an intrauterine influence on glucose homeostasis and perhaps on insulin resistance in humans.
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