ArticleLipids1999
Cell proliferation, differentiation, and apoptosis are modified by n-3 polyunsaturated fatty acids in normal colonic mucosa.
Article in Lipids, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 80 citations in OpenAlex.
- Eicosapentaenoic acid (EPA) reduces crypt cell proliferation and increases apoptosis in normal colonic mucosa in subjects with a history of colorectal adenomas.International journal of colorectal disease · 2007Trial
- Lipidomic insights into the immune response and pearl formation in transplanted pearl oysterFrontiers in immunology · 2022Article
- Unsaturated fatty acids as a co-therapeutic agents in cancer treatment.Molecular biology reports · 2021Review
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- Effects of low-to-moderate ethanol consumption on colonic growth and gene expression in young adult and middle-aged male rats.PloS one · 2020Article
- Intestinal homeostasis is restored in mice following a period of intestinal growth induced by orally administered Emu Oil.Experimental biology and medicine (Maywood, N.J.) · 2018Article
- Article
- Involvement of apoptotic pathways in docosahexaenoic acid-induced benefit in prostate cancer: Pathway-focused gene expression analysis using RTLipids in health and disease · 2017Article
- Docosahexaenoic Acid Inhibits Vascular Smooth Muscle Cell Proliferation Induced by Glucose Variability.The open biochemistry journal · 2017Article
- Krill oil extract suppresses cell growth and induces apoptosis of human colorectal cancer cells.BMC complementary and alternative medicine · 2016Article
- The Effect of Marine Derived n-3 Fatty Acids on Adipose Tissue Metabolism and Function.Journal of clinical medicine · 2015Review
- Lipid-rich diet enhances L-cell density in obese subjects and in mice through improved L-cell differentiation.Journal of nutritional science · 2015Article
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- Regulation of colorectal cancer cell apoptosis by the n-3 polyunsaturated fatty acids Docosahexaenoic and Eicosapentaenoic.Cancer prevention research (Philadelphia, Pa.) · 2009Article
- Anticancer properties of propofol-docosahexaenoate and propofol-eicosapentaenoate on breast cancer cells.Breast cancer research : BCR · 2005Article
- Cell-cycle arrest in Jurkat leukaemic cells: a possible role for docosahexaenoic acid.The Biochemical journal · 2003Article
- Consumption of an omega-3 fatty acids product, INCELL AAFA, reduced side-effects of CPT-11 (irinotecan) in mice.British journal of cancer · 2002Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Supplementation with low doses of eicosapentaenoic (EPA) or docosahexaenoic (DHA) acid was used here to investigate changes in epithelial proliferation, differentiation, and apoptosis in normal rat colonic mucosa. ACI/T rats received by oral administration low doses of purified EPA or DHA ethyl esters (1 g/kg body weight) and colonic mucosa was analyzed for cell proliferation, differentiation, and apoptosis. n-3 Polyunsaturated fatty acid incorporation into membrane phospholipids was investigated as reflections of fatty acid metabolism. Both EPA and DHA suppressed colonocyte proliferation and increased the numbers of differentiating and apoptotic cells without modification of the crypt morphology and the number of cells per crypt columns. A significant incorporation of the supplemented fatty acids into total phospholipids was observed. This enrichment was accompanied by a decreased content in arachidonic acid. The observation that EPA and DHA do not alter crypt morphology although they modify cell turnover in normal colonic mucosa suggests a possible use of these fatty acids as dietary chemopreventive agents.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.