ArticleGut1999
Reduced oxidative and nitrosative damage in murine experimental colitis in the absence of inducible nitric oxide synthase.
Article in Gut, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06335160 (Clinical Study to Evaluate the Possible Efficacy and Safety of Mebendazole in Patients With Ulcerative Colitis Treated With Mesalamine), which is not on this map. Cited by 37 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Clinical Study to Evaluate the Possible Efficacy and Safety of Mebendazole in Patients With Ulcerative Colitis Treated With Mesalamine
Who cites it
37 citing papers in PubMed, 135 citations in OpenAlex.
- Effect of rebamipide in treatment of Helicobacter pylori-associated duodenal ulcer: attenuation of chemokine expression and nitrosative damage.Digestive diseases and sciences · 2002Trial
- Environmental Exposures and Oxidative Stress in Retinal and Optic Nerve Diseases: Mechanisms, Consequences, and Therapeutic Opportunities.Antioxidants (Basel, Switzerland) · 2026Review
- Article
- Chronic Exposure to Nitric Oxide Induces P53 Mutations and Malignant-like Features in Human Breast Epithelial Cells.Biomolecules · 2023Article
- Nitric oxide favours tumour-promoting inflammation through mitochondria-dependent and -independent actions on macrophages.Redox biology · 2022Article
- Phosphatidylserine externalized on the colonic capillaries as a novel pharmacological target for IBD therapy.Signal transduction and targeted therapy · 2021Article
- Article
- Unique Regulation of Enterocyte Brush Border Membrane Na-Glutamine and Na-Alanine Co-Transport by Peroxynitrite during Chronic Intestinal Inflammation.International journal of molecular sciences · 2019Article
- Article
- Downregulation of L-arginine metabolism in dendritic cells induces tolerance to exogenous antigen.International journal of immunopathology and pharmacology · 2017Article
- Altered cGMP dynamics at the plasma membrane contribute to diarrhea in ulcerative colitis.The American journal of pathology · 2015Article
- Chemistry meets biology in colitis-associated carcinogenesis.Free radical research · 2013Review
- Intestinal myofibroblasts produce nitric oxide in response to combinatorial cytokine stimulation.Journal of cellular physiology · 2013Article
- Intrarectal nitric oxide administration prevents cellular infiltration but not colonic injury during dextran sodium sulfate colitis.Digestive diseases and sciences · 2012Article
- Ion channel remodeling in gastrointestinal inflammation.Neurogastroenterology and motility · 2010Review
- Resveratrol suppresses colitis and colon cancer associated with colitis.Cancer prevention research (Philadelphia, Pa.) · 2010Article
- Colorectal carcinoma development in inducible nitric oxide synthase-deficient mice with dextran sulfate sodium-induced ulcerative colitis.Molecular carcinogenesis · 2007Article
- Deoxycholate-induced colitis is markedly attenuated in Nos2 knockout mice in association with modulation of gene expression profiles.Digestive diseases and sciences · 2007Article
- Nitric oxide and peroxynitrite in health and disease.Physiological reviews · 2007Review
- Antioxidant therapy with N-acetylcysteine plus mesalamine accelerates mucosal healing in a rodent model of colitis.Digestive diseases and sciences · 2006Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundOxidative and nitrosative stress have been implicated in the pathogenesis of inflammatory bowel diseases.
aimsTo study the role of nitric oxide (NO) derived from inducible NO synthase (iNOS) in an experimental model of murine enterocolitis.
methodsTrinitrobenzene sulphonic acid (TNBS) was instilled per rectum to induce a lethal colitis in iNOS deficient mice and in wild type controls. The distal colon was evaluated for histological evidence of inflammation, iNOS expression and activity, tyrosine nitration and malondialdehyde formation (as indexes of nitrosative and oxidative stress), myeloperoxidase activity (as index of neutrophil infiltration), and tissue localisation of intercellular adhesion molecule 1 (ICAM-1).
resultsTNBS administration induced a high mortality and weight loss associated with a severe colonic mucosal erosion and ulceration, increased myeloperoxidase activity, increased concentrations of malondialdehyde, and an intense staining for nitrotyrosine and ICAM-1 in wild type mice. Genetic ablation of iNOS gene conferred to mice a significant resistance to TNBS induced lethality and colonic damage, and notably reduced nitrotyrosine formation and concentrations of malondialdehyde; it did not, however, affect neutrophil infiltration and intestinal ICAM-1 expression in the injured tissue.
conclusionData show that activation of iNOS is required for nitrosative and oxidative damage in experimental colitis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.