ArticleImmunity1999
Distinct signals mediate maturation and allelic exclusion in lymphocyte progenitors.
Article in Immunity, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 85 citations in OpenAlex.
- Transcription factors and target genes of pre-TCR signaling.Cellular and molecular life sciences : CMLS · 2015Review
- The importance of the Erk pathway in the development of linker for activation of T cells-mediated autoimmunity.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- TEC and MAPK Kinase Signalling Pathways in T helper (TJournal of clinical & cellular immunology · 2012Article
- Interaction of Ras with p110γ is required for thymic β-selection in the mouse.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
- Vstm3 is a member of the CD28 family and an important modulator of T-cell function.European journal of immunology · 2011Article
- TCR beta feedback signals inhibit the coupling of recombinationally accessible V beta 14 segments with DJ beta complexes.Journal of immunology (Baltimore, Md. : 1950) · 2010Article
- Critical roles of the PI3K/Akt signaling pathway in T cell development.Immunology letters · 2008Review
- B-Raf-mediated signaling pathway regulates T cell development.European journal of immunology · 2008Article
- Calcineurin sets the bandwidth for discrimination of signals during thymocyte development.Nature · 2007Article
- Myc stimulates B lymphocyte differentiation and amplifies calcium signaling.The Journal of cell biology · 2007Article
- ShcA mediates the dominant pathway to extracellular signal-regulated kinase activation during early thymic development.Molecular and cellular biology · 2006Article
- Progression of regulatory gene expression states in fetal and adult pro-T-cell development.Immunological reviews · 2006Review
- Regulated costimulation in the thymus is critical for T cell development: dysregulated CD28 costimulation can bypass the pre-TCR checkpoint.Journal of immunology (Baltimore, Md. : 1950) · 2005Article
- Deregulated expression of RasGRP1 initiates thymic lymphomagenesis independently of T-cell receptors.Oncogene · 2005Article
- The Vav family: at the crossroads of signaling pathways.Immunologic research · 2005Review
- Ras activation in Jurkat T cells following low-grade stimulation of the T-cell receptor is specific to N-Ras and occurs only on the Golgi apparatus.Molecular and cellular biology · 2004Article
- Selection of B lymphocytes in the periphery is determined by the functional capacity of the B cell antigen receptor.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- B-cell antigen-receptor signalling in lymphocyte development.Immunology · 2003Review
- Vav1/2/3-null mice define an essential role for Vav family proteins in lymphocyte development and activation but a differential requirement in MAPK signaling in T and B cells.The Journal of experimental medicine · 2003Article
- Modulation of T-lymphocyte development, growth and cell size by the Myc antagonist and transcriptional repressor Mad1.The EMBO journal · 2002Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 4 institutions in 1 country.
Funding
Abstract
Successful in-frame rearrangement of immunoglobulin heavy chain genes or T cell antigen receptor (TCR) beta chain genes in lymphocyte progenitors results in formation of pre-BCR and pre-TCR complexes. These complexes signal progenitor cells to mature, expand in cell number, and suppress further rearrangements at the immunoglobulin heavy chain or TCRbeta chain loci, thereby ensuring allelic exclusion. We used transgenic expression of a constitutively active form of c-Raf-1 (Raf-CAAX) to demonstrate that activation of the Map kinase pathway can stimulate both maturation and expansion of B and T lymphocytes, even in the absence of pre-TCR or pre-BCR formation. However, the same Raf signal did not mediate allelic exclusion. We conclude that maturation of lymphocyte progenitors and allelic exclusion require distinct signals.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.