ArticleThe Journal of cell biology1999
Genomic organization, expression, and analysis of the troponin C gene pat-10 of Caenorhabditis elegans.
Article in The Journal of cell biology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 48 citations in OpenAlex.
- Identification of the Extracellular Nuclease Influencing Soaking RNA Interference Efficiency inInternational journal of molecular sciences · 2022Article
- Kettin, the large actin-binding protein with multiple immunoglobulin domains, is essential for sarcomeric actin assembly and larval development in Caenorhabditis elegans.The FEBS journal · 2020Article
- Alternative splicing of the Caenorhabditis elegans lev-11 tropomyosin gene is regulated in a tissue-specific manner.Cytoskeleton (Hoboken, N.J.) · 2018Article
- Tropomyosin isoforms differentially affect muscle contractility in the head and body regions of the nematode Caenorhabditis elegans.Molecular biology of the cell · 2018Article
- Functional redundancy and nonredundancy between two Troponin C isoforms inMolecular biology of the cell · 2017Article
- De novo analysis of the transcriptome of Pratylenchus zeae to identify transcripts for proteins required for structural integrity, sensation, locomotion and parasitism.Molecular plant pathology · 2016Article
- Molecular evolution of troponin I and a role of its N-terminal extension in nematode locomotion.Cytoskeleton (Hoboken, N.J.) · 2016Article
- HSF-1-mediated cytoskeletal integrity determines thermotolerance and life span.Science (New York, N.Y.) · 2014Article
- Regulation of structure and function of sarcomeric actin filaments in striated muscle of the nematode Caenorhabditis elegans.Anatomical record (Hoboken, N.J. : 2007) · 2014Review
- Two actin-interacting protein 1 isoforms function redundantly in the somatic gonad and are essential for reproduction in Caenorhabditis elegans.Cytoskeleton (Hoboken, N.J.) · 2014Article
- Large-scale gene knockdown in C. elegans using dsRNA feeding libraries to generate robust loss-of-function phenotypes.Journal of visualized experiments : JoVE · 2013Article
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- Role of phosphatidylinositol-4-phosphate 5' kinase (ppk-1) in ovulation of Caenorhabditis elegans.Experimental cell research · 2007Article
- Structural components of the nonstriated contractile apparatuses in the Caenorhabditis elegans gonadal myoepithelial sheath and their essential roles for ovulation.Developmental dynamics : an official publication of the American Association of Anatomists · 2007Article
- Diversification and independent evolution of troponin C genes in insects.Journal of molecular evolution · 2005Article
- Tropomyosin and troponin are required for ovarian contraction in the Caenorhabditis elegans reproductive system.Molecular biology of the cell · 2004Article
- Disruption of Caenorhabditis elegans muscle structure and function caused by mutation of troponin I.Biophysical journal · 2004Article
- Troponin C in different insect muscle types: identification of two isoforms in Lethocerus, Drosophila and Anopheles that are specific to asynchronous flight muscle in the adult insect.The Biochemical journal · 2003Article
- UNC112. A new regulator of cell-extracellular matrix adhesions?The Journal of cell biology · 2000Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have cloned and characterized the troponin C gene, pat-10 of the nematode Caenorhabditis elegans. At the amino acid level nematode troponin C is most similar to troponin C of Drosophila (45% identity) and cardiac troponin C of vertebrates. Expression studies demonstrate that this troponin is expressed in body wall muscle throughout the life of the animal. Later, vulval muscles and anal muscles also express this troponin C isoform. The structural gene for this troponin is pat-10 and mutations in this gene lead to animals that arrest as twofold paralyzed embryos late in development. We have sequenced two of the mutations in pat-10 and both had identical two mutations in the gene; one changes D64 to N and the other changes W153 to a termination site. The missense alteration affects a calcium-binding site and eliminates calcium binding, whereas the second mutation eliminates binding to troponin I. These combined biochemical and in vivo studies of mutant animals demonstrate that this troponin is essential for proper muscle function during development.
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