ArticleThe Journal of cell biology1999
Age-related atrophy of motor axons in mice deficient in the mid-sized neurofilament subunit.
Article in The Journal of cell biology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
25 citing papers in PubMed, 79 citations in OpenAlex.
- From Axonal Growth to Neurodegeneration: The Dual Role of Neurofilament Dynamics in Health and Disease.NeuroSci · 2026Review
- Neurodegeneration and its potential markers in the diagnosing of secondary progressive multiple sclerosis. A review.Frontiers in molecular neuroscience · 2023Review
- Neurofilament Proteins as Biomarkers to Monitor Neurological Diseases and the Efficacy of Therapies.Frontiers in neuroscience · 2021Review
- Local Acceleration of Neurofilament Transport at Nodes of Ranvier.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- An automated method for the quantification of transgene expression in motor axons of the peripheral nerve.Journal of neuroscience methods · 2018Article
- Sex matters: repetitive mild traumatic brain injury in adolescent rats.Annals of clinical and translational neurology · 2017Article
- Neurofilaments and Neurofilament Proteins in Health and Disease.Cold Spring Harbor perspectives in biology · 2017Review
- Ultrastructural Characterization of Zika Virus Replication Factories.Cell reports · 2017Article
- Early-Life Stress Perturbs Key Cellular Programs in the Developing Mouse Hippocampus.Developmental neuroscience · 2015Article
- Statistical physics approach to quantifying differences in myelinated nerve fibers.Scientific reports · 2014Article
- Merlin isoform 2 in neurofibromatosis type 2-associated polyneuropathy.Nature neuroscience · 2013Article
- Strain-specific hyperkyphosis and megaesophagus in Add1 null mice.Genesis (New York, N.Y. : 2000) · 2012Article
- Impact of very old age on the expression of cervical spinal cord cell markers in rats.Journal of chemical neuroanatomy · 2009Article
- Age-dependent changes in neuronal distribution of CacyBP/SIP: comparison to tubulin and the tau protein.Journal of neural transmission (Vienna, Austria : 1996) · 2008Article
- Review of the multiple aspects of neurofilament functions, and their possible contribution to neurodegeneration.Molecular neurobiology · 2008Review
- Axonal neurofilaments control multiple fiber properties but do not influence structure or spacing of nodes of Ranvier.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007Article
- Axons break in animals lacking beta-spectrin.The Journal of cell biology · 2007Article
- Enriched expression and developmental regulation of the middle-weight neurofilament (NF-M) gene in song control nuclei of the zebra finch.The Journal of comparative neurology · 2007Article
- Atrophy of large myelinated axons in metallothionein-I, II knockout mice.Cellular and molecular neurobiology · 2005Article
- BetaIV spectrins are essential for membrane stability and the molecular organization of nodes of Ranvier.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2004Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Neurofilaments are central determinants of the diameter of myelinated axons. It is less clear whether neurofilaments serve other functional roles such as maintaining the structural integrity of axons over time. Here we show that an age-dependent axonal atrophy develops in the lumbar ventral roots of mice with a null mutation in the mid-sized neurofilament subunit (NF-M) but not in animals with a null mutation in the heavy neurofilament subunit (NF-H). Mice with null mutations in both genes develop atrophy in ventral and dorsal roots as well as a hind limb paralysis with aging. The atrophic process is not accompanied by significant axonal loss or anterior horn cell pathology. In the NF-M-null mutant atrophic ventral root, axons show an age-related depletion of neurofilaments and an increased ratio of microtubules/neurofilaments. By contrast, the preserved dorsal root axons of NF-M-null mutant animals do not show a similar depletion of neurofilaments. Thus, the lack of an NF-M subunit renders some axons selectively vulnerable to an age-dependent atrophic process. These studies argue that neurofilaments are necessary for the structural maintenance of some populations of axons during aging and that the NF-M subunit is especially critical.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.