ArticleThe Journal of cell biology1999
Kinetochore fibers are not involved in the formation of the first meiotic spindle in mouse oocytes, but control the exit from the first meiotic M phase.
Article in The Journal of cell biology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
68 citing papers in PubMed, 171 citations in OpenAlex.
- Tuning Meiotic Checkpoints: Evolutionary Costs and Mechanistic Trade-Offs.Annual review of genetics · 2026Review
- MOS is a key regulator of meiotic midbody assembly and prevents abnormal divisions in mouse eggs and their polar bodies.Journal of cell science · 2026Article
- Article
- "JessMethods in molecular biology (Clifton, N.J.) · 2025Article
- Loss of centromeric RNA activates the spindle assembly checkpoint in mammalian female meiosis I.The Journal of cell biology · 2021Article
- Stable kinetochore-microtubule attachments restrict MTOC position and spindle elongation in oocytes.EMBO reports · 2021Article
- Spindle assembly and chromosome dynamics during oocyte meiosis.Current opinion in cell biology · 2019Review
- The molecular architecture of the meiotic spindle is remodeled during metaphase arrest in oocytes.The Journal of cell biology · 2019Article
- Chromokinesin Kif4 promotes proper anaphase in mouse oocyte meiosis.Molecular biology of the cell · 2019Article
- Aneuploidy in Oocytes Is Prevented by Sustained CDK1 Activity through Degron Masking in Cyclin B1.Developmental cell · 2019Article
- Updating the markers for oocyte quality evaluation: intracellular temperature as a new index.Reproductive medicine and biology · 2018Review
- Using Mouse Oocytes to Assess Human Gene Function During Meiosis I.Journal of visualized experiments : JoVE · 2018Article
- Mechanisms of kinetochore-microtubule attachment errors in mammalian oocytes.Development, growth & differentiation · 2018Review
- The chromosomal basis of meiotic acentrosomal spindle assembly and function in oocytes.Chromosoma · 2017Review
- Meiotic spindle assembly and chromosome segregation in oocytes.The Journal of cell biology · 2016Review
- Article
- Oocyte Maturation and Development.F1000Research · 2016Review
- Oocyte Meiotic Spindle Assembly and Function.Current topics in developmental biology · 2016Review
- The microtubule catastrophe promoter Sentin delays stable kinetochore-microtubule attachment in oocytes.The Journal of cell biology · 2015Article
- Lateral and End-On Kinetochore Attachments Are Coordinated to Achieve Bi-orientation in Drosophila Oocytes.PLoS genetics · 2015Article
8 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
During meiosis, two successive divisions occur without any intermediate S phase to produce haploid gametes. The first meiotic division is unique in that homologous chromosomes are segregated while the cohesion between sister chromatids is maintained, resulting in a reductional division. Moreover, the duration of the first meiotic M phase is usually prolonged when compared with mitotic M phases lasting 8 h in mouse oocytes.We investigated the spindle assembly pathway and its role in the progression of the first meiotic M phase in mouse oocytes. During the first 4 h, a bipolar spindle forms and the chromosomes congress near the equatorial plane of the spindle without stable kinetochore- microtubule end interactions. This late prometaphase spindle is then maintained for 4 h with chromosomes oscillating in the central region of the spindle. The kinetochore-microtubule end interactions are set up at the end of the first meiotic M phase (8 h after entry into M phase). This event allows the final alignment of the chromosomes and exit from metaphase. The continuous presence of the prometaphase spindle is not required for progression of the first meiotic M phase. Finally, the ability of kinetochores to interact with microtubules is acquired at the end of the first meiotic M phase and determines the timing of polar body extrusion.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.