ArticleThe Plant cell1999
Overexpression of Arabidopsis hexokinase in tomato plants inhibits growth, reduces photosynthesis, and induces rapid senescence.
Article in The Plant cell, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 123 papers.
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123 citing papers in PubMed, 376 citations in OpenAlex.
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- Discovering novel genomic regions explaining adaptation of bread wheat to conservation agriculture through GWAS.Scientific reports · 2024Article
- For a Colorful Life: Recent Advances in Anthocyanin Biosynthesis during Leaf Senescence.Biology · 2024Review
- Dihydroporphyrin iron (III) enhances low temperature tolerance by increasing carbon and nitrogen metabolism inFrontiers in plant science · 2024Article
- Article
- Structure and Expression Analysis ofInternational journal of molecular sciences · 2023Article
- HEXOKINASE1 and glucose-6-phosphate fuel plant growth and development.Development (Cambridge, England) · 2023Article
- Genome-Wide Characterization of Soybean Hexokinase Genes Reveals a Positive Role ofPlants (Basel, Switzerland) · 2023Article
- Abiotic Stress-Induced Leaf Senescence: Regulatory Mechanisms and Application.International journal of molecular sciences · 2023Review
- Comparative transcriptome profiling analysis provides insight into the mechanisms for sugar change in Chinese jujube (Ziziphus jujuba Mill.) under rain-proof cultivation.The plant genome · 2023Article
- Metabolic footprints in phosphate-starved plants.Physiology and molecular biology of plants : an international journal of functional plant biology · 2023Review
- Identification and Expression Analysis of Hexokinases Family inPlants (Basel, Switzerland) · 2023Article
- Combined Metabolome and Transcriptome Analysis Elucidates Sugar Accumulation in Wucai (International journal of molecular sciences · 2023Article
- Downregulation ofFrontiers in plant science · 2023Article
- Comprehensive analysis of the WRKY gene family inFrontiers in plant science · 2023Article
63 more citing papers are in PubMed but not listed here.
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sugars are key regulatory molecules that affect diverse processes in higher plants. Hexokinase is the first enzyme in hexose metabolism and may be a sugar sensor that mediates sugar regulation. We present evidence that hexokinase is involved in sensing endogenous levels of sugars in photosynthetic tissues and that it participates in the regulation of senescence, photosynthesis, and growth in seedlings as well as in mature plants. Transgenic tomato plants overexpressing the Arabidopsis hexokinase-encoding gene AtHXK1 were produced. Independent transgenic plants carrying single copies of AtHXK1 were characterized by growth inhibition, the degree of which was found to correlate directly to the expression and activity of AtHXK1. Reciprocal grafting experiments suggested that the inhibitory effect occurred when AtHXK1 was expressed in photosynthetic tissues. Accordingly, plants with increased AtHXK1 activity had reduced chlorophyll content in their leaves, reduced photosynthesis rates, and reduced photochemical quantum efficiency of photosystem II reaction centers compared with plants without increased AtHXK1 activity. In addition, the transgenic plants underwent rapid senescence, suggesting that hexokinase is also involved in senescence regulation. Fruit weight, starch content in young fruits, and total soluble solids in mature fruits were also reduced in the transgenic plants. The results indicate that endogenous hexokinase activity is not rate limiting for growth; rather, they support the role of hexokinase as a regulatory enzyme in photosynthetic tissues, in which it regulates photosynthesis, growth, and senescence.
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