ArticleBritish journal of pharmacology1999
Protective effects of a superoxide dismutase mimetic and peroxynitrite decomposition catalysts in endotoxin-induced intestinal damage.
Article in British journal of pharmacology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 132 citations in OpenAlex.
- Differential effect of targeting cisplatin-induced nitrative stress using MnTBAP in auditory and cancer cells.Current research in toxicology · 2025Article
- The Interplay of Oxidative Stress and ROS Scavenging: Antioxidants as a Therapeutic Potential in Sepsis.Vaccines · 2022Review
- Impact of MnTBAP and Baricitinib Treatment on Hutchinson-Gilford Progeria Fibroblasts.Pharmaceuticals (Basel, Switzerland) · 2022Article
- Protective Effect of Antioxidants in Nitric Oxide/COX-2 Interaction during Inflammatory Pain: The Role of Nitration.Antioxidants (Basel, Switzerland) · 2020Article
- Arctic ground squirrel resist peroxynitrite-mediated cell death in response to oxygen glucose deprivation.Free radical biology & medicine · 2017Article
- Nitrosative Stress-Induced Disruption of Baroreflex Neural Circuits in a Rat Model of Hepatic Encephalopathy: A DTI Study.Scientific reports · 2017Article
- Therapeutic targeting of inflammation and tryptophan metabolism in colon and gastrointestinal cancer.Translational research : the journal of laboratory and clinical medicine · 2016Review
- Preservation of renal blood flow by the antioxidant EUK-134 in LPS-treated pigs.International journal of molecular sciences · 2015Article
- Protective effect of metalloporphyrins against cisplatin-induced kidney injury in mice.PloS one · 2014Article
- Testosterone-induced effects on lipids and inflammation.Mediators of inflammation · 2013Review
- Effects of a potent peroxynitrite decomposition catalyst in murine models of endotoxemia and sepsis.Shock (Augusta, Ga.) · 2011Article
- The effects of amlodipine on the biochemical and histopathological changes in the rabbit ileum subjected to ischemia-reperfusion.The Eurasian journal of medicine · 2011Article
- Pathophysiological roles of peroxynitrite in circulatory shock.Shock (Augusta, Ga.) · 2010Review
- Superoxide and Nitric Oxide Involvement in Enhancing of N-methyl-D-aspartate Receptor-Mediated Central Sensitization in the Chronic Post-ischemia Pain Model.The Korean journal of pain · 2010Article
- Superoxide signaling in pain is independent of nitric oxide signaling.Neuroreport · 2009Article
- Role of nitroso radicals as drug targets in circulatory shock.British journal of pharmacology · 2009Review
- Superoxide dismutases: a physiopharmacological update.Journal of physiology and biochemistry · 2009Review
- Peroxynitrite and opiate antinociceptive tolerance: a painful reality.Archives of biochemistry and biophysics · 2009Review
- Alpha-lipoic acid and ebselen prevent ischemia/reperfusion injury in the rat intestine.Surgery today · 2008Article
- Nitric oxide and peroxynitrite in health and disease.Physiological reviews · 2007Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
1. The relative contributions of superoxide anion (O2-) and peroxynitrite (PN) were evaluated in the pathogenesis of intestinal microvascular damage caused by the intravenous injection of E. coli lipopolysaccharide (LPS) in rats. The superoxide dismutase mimetic (SODm) SC-55858 and the active peroxynitrite decomposition catalysts 5,10,15,20-tetrakis(2,4,6-trimethyl-3,5-disulphonatophenyl)-por phyrinato iron (III) and 5,10,15,20-tetrakis(N-methyl-4'-pyridyl)-porphyrinato iron (III) (FeTMPS, FeTMPyP respectively) were used to assess the roles of O2- and PN respectively. 2. The intravenous injection of LPS elicited an inflammatory response that was characterized by a time-dependent infiltration of neutrophils, lipid peroxidation, microvascular leakage (indicative of microvascular damage), and epithelial cell injury in both the duodenum and jejunum. 3. Administration of the SODm SC-55858, FeTMPS or FeTMPyP at 3 h post LPS reduced the subsequent increase in microvascular leakage, lipid peroxidation and epithelial cell injury. Inactive peroxynitrite decomposition catalysts exhibited no protective effects. Only, SC-55858 inhibited neutrophil infiltration. 4. Our results suggest that O2 and peroxynitrite play a significant role in the pathogenesis of duodenal and intestinal injury during endotoxaemia and that their remoyal by SODm and peroxynitrite decomposition catalysts offers a novel approach to the treatment of septic shock or clinical conditions of gastrointestinal inflammation. Furthermore, the remarkable protection of the intestinal epithelium by these agents suggests their use during chemo- and radiation therapy, cancer treatments characterized by gastrointestinal damage. Potential mechanisms through which these radicals evoke damage are discussed.
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