ArticleBritish journal of pharmacology1999
Pharmacological evidence for the 5-HT7 receptor mediating smooth muscle relaxation in canine cerebral arteries.
Article in British journal of pharmacology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 89 citations in OpenAlex.
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- Migraine signaling pathways: amino acid metabolites that regulate migraine and predispose migraineurs to headache.Molecular and cellular biochemistry · 2022Review
- 5-HTJournal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi · 2021Article
- Role of 5-HTMolecular medicine (Cambridge, Mass.) · 2019Review
- Pharmacologic assessment of bovine ruminal and mesenteric vascular serotonin receptor populations.Journal of animal science · 2018Article
- 5-HT causes splanchnic venodilation.American journal of physiology. Heart and circulatory physiology · 2017Article
- Elucidation of the profound antagonism of contractile action of phenylephrine in rat aorta effected by an atypical sympathomimetic decongestant.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2017Article
- Low-basicity 5-HTScientific reports · 2017Article
- Serotonin 5-HT7 receptor agonist, LP-211, exacerbates Na(+), K(+)-ATPase/Mg(2+)-ATPase imbalances in spinal cord-injured male rats.Diagnostic pathology · 2015Article
- 5-HT is a potent relaxant in rat superior mesenteric veins.Pharmacology research & perspectives · 2015Article
- Vasoconstrictor and vasodilator responses to tryptamine of rat-isolated perfused mesentery: comparison with tyramine and β-phenylethylamine.British journal of pharmacology · 2012Article
- Serotonin and blood pressure regulation.Pharmacological reviews · 2012Review
- Characteristics of the actions by which 5-HT affects electrical and mechanical activities in rabbit jugular vein.British journal of pharmacology · 2011Article
- Role of the 5-HT7 receptor in the central nervous system: from current status to future perspectives.Molecular neurobiology · 2011Review
- Serotonin 5-HT7 receptor agents: Structure-activity relationships and potential therapeutic applications in central nervous system disorders.Pharmacology & therapeutics · 2011Review
- The 5-HT7 receptor and disorders of the nervous system: an overview.Psychopharmacology · 2009Review
- Potassium channels are involved in testosterone-induced vasorelaxation of human umbilical artery.Naunyn-Schmiedeberg's archives of pharmacology · 2008Article
- Differential profile of typical, atypical and third generation antipsychotics at human 5-HT7a receptors coupled to adenylyl cyclase: detection of agonist and inverse agonist properties.Naunyn-Schmiedeberg's archives of pharmacology · 2007Article
- 5-HT7 receptor-mediated dilatation in the middle meningeal artery of anesthetized rats.European journal of pharmacology · 2007Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
1. We investigated in the present study whether 5-HT is able to exert direct relaxant responses in canine basilar and middle cerebral arteries via the 5-HT7 receptor. 2. In arterial rings deprived of endothelium and pre-contracted with prostaglandin F2 alpha (2 microM), 5-HT, 5-carboxamidotryptamine (5-CT), 5-methoxytryptamine, sumatriptan or alpha-methyl-5-HT produced further increase in tone and/or slight relaxation. Blockade of 5-HT1B 1D and 5-HT2A receptors with GR127935 (1 microM) and ketanserin (0.1 microM), respectively, antagonized the vasoconstrictor component of the response and unmasked a concentration-dependent relaxation to 5-HT, 5-CT and 5-methoxytryptamine; sumatriptan and alpha-methyl-5-HT remained inactive as relaxant agonists. The rank order of agonist potency in both arteries was 5-CT > 5-HT > 5-methoxytryptamine >> sumatriptan > or = alpha-methyl-5-HT. 3. In dog basilar artery, pre-incubated with GR127935 (1 microM) and ketanserin (0.1 microM) and precontracted with prostaglandin F2 alpha (2 microM), the 5-HT7 ligands, clozapine (1 microM), mesulergine (0.3 microM), methiothepin (3 nM), risperidone (3 nM), spiperone (1 microM) and LY215840 (10-100 nM), produced significant rightward shifts of the concentration-response curves for 5-HT and 5-CT. Only methiothepin and risperidone reduced significantly the maximum relaxant response (Emax), whilst the other drugs behaved as competitive antagonists with affinity values (pKB) that significantly correlated with their binding affinity (pKi) at recombinant 5-HT7 receptors. 4. These data disclosing the involvement of the 5-HT7 receptor in cerebrovascular relaxation may be strongly relevant in the light of: (1) the involvement of 5-HT in migraine; (2) the putative linkage between cephalovascular vasodilatation and migraine headache; and (3) the relatively high 5-HT7 receptor affinity of migraine prophylactic 5-HT antagonists.
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