ArticleBritish journal of pharmacology1999
Augmented acetylcholine-induced, Rho-mediated Ca2+ sensitization of bronchial smooth muscle contraction in antigen-induced airway hyperresponsive rats.
Article in British journal of pharmacology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
43 citing papers in PubMed, 146 citations in OpenAlex.
- Long-Acting Muscarinic Antagonists for the Treatment of Difficult-to-Treat and Severe Asthma: A Narrative Review Focusing on Inflammation from Bench to Bedside.Journal of inflammation research · 2026Review
- Myocd regulates airway smooth muscle cell remodeling in response to chronic asthmatic injury.The Journal of pathology · 2023Article
- Down-regulation of miR-140-3p is a cause of the interlukin-13-induced up-regulation of RhoA protein in bronchial smooth muscle cells.Small GTPases · 2022Article
- The role and mechanism of 1,25-dihydroxyvitamin DTranslational pediatrics · 2021Article
- Implications of immune-inflammatory responses in smooth muscle dysfunction and disease.Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi · 2019Article
- Sustained exposure to prostaglandin DJournal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi · 2019Article
- Prostaglandin D₂ Induces CaInternational journal of molecular sciences · 2018Article
- Rho signaling research: history, current status and future directions.FEBS letters · 2018Review
- Elastase alters contractility and promotes an inflammatory synthetic phenotype in airway smooth muscle tissues.American journal of physiology. Lung cellular and molecular physiology · 2018Article
- Mechanisms underlying the pathogenesis of hyper-contractility of bronchial smooth muscle in allergic asthma.Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi · 2017Review
- Effect of Rho-kinase inhibition on complexity of breathing pattern in a guinea pig model of asthma.PloS one · 2017Article
- MicroRNAs in Allergic Disease.Current allergy and asthma reports · 2016Review
- No evidence for altered intracellular calcium-handling in airway smooth muscle cells from human subjects with asthma.BMC pulmonary medicine · 2015Article
- Statins in Asthma: Potential Beneficial Effects and Limitations.Pulmonary medicine · 2015Review
- Review
- Augmented bronchial smooth muscle contractility induced by aqueous cigarette smoke extract in rats.Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi · 2014Article
- Airway smooth muscle in the pathophysiology and treatment of asthma.Journal of applied physiology (Bethesda, Md. : 1985) · 2013Review
- Mfge8 suppresses airway hyperresponsiveness in asthma by regulating smooth muscle contraction.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Airway smooth muscle hypercontractility in asthma.Journal of allergy · 2013Article
- Point: alterations in airway smooth muscle phenotype do/do not cause airway hyperresponsiveness in asthma.Journal of applied physiology (Bethesda, Md. : 1985) · 2012Review
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Treatment with acetylcholine (ACh) of a beta-escin-permeabilized intrapulmonary bronchial smooth muscle of the rat induced force when the Ca2+ concentration was clamped at 1 microM. The ACh-induced Ca2+ sensitization of myofilaments was significantly greater in antigen-induced airway hyperresponsive rats than in control rats. The ACh-induced Ca2+ sensitization was completely blocked by treatment with Clostridium botulinum C3 exoenzyme, an inactivator of Rho family of proteins. Moreover, the protein level of RhoA in the intrapulmonary bronchi was significantly increased in the airway hyperresponsive rats. Thus, increased airway smooth muscle contractility observed in asthmatics may be related to augmented agonist-induced, Rho-mediated Ca2+ sensitization of myofilaments.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.