ArticleGenome research1999
Physical and meiotic mapping of the region of human chromosome 4q11-q13 encompassing the vitamin D binding protein DBP/Gc-globulin and albumin multigene cluster.
Article in Genome research, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed.
- Vitamin D Binding Protein Gene Polymorphisms (rs4588 and rs7041) and VDBP Levels in Total Hip Replacement Outcomes.Nutrients · 2025Article
- A new SOFrontiers in physiology · 2025Article
- Vitamin D binding protein in psychiatric and neurological disorders: Implications for diagnosis and treatment.Genes & diseases · 2024Review
- Biochemical Screening for Fetal Trisomy 21: Pathophysiology of Maternal Serum Markers and Involvement of the Placenta.International journal of molecular sciences · 2023Review
- Transcriptomic analysis reveal the responses of dendritic cells to VDBP.Genes & genomics · 2022Article
- Assessment and Monitoring of Response to Systemic Treatment in Advanced Hepatocellular Carcinoma: Current Insights.Journal of hepatocellular carcinoma · 2022Review
- Vitamin D Binding Protein (VDBP) and Its Gene Polymorphisms-The Risk of Malignant Tumors and Other Diseases.International journal of molecular sciences · 2020Review
- The effect of vitamin D pathway genes and deferasirox pharmacogenetics on liver iron in thalassaemia major patients.The pharmacogenomics journal · 2019Article
- Role of CYP24A1, VDR and GC gene polymorphisms on deferasirox pharmacokinetics and clinical outcomes.The pharmacogenomics journal · 2018Article
- Assessment of Vitamin D-Binding Protein and Early Prediction of Nephropathy in Type 2 Saudi Diabetic Patients.Journal of diabetes research · 2018Article
- Current Controversies: Are Free Vitamin Metabolite Levels a More Accurate Assessment of Vitamin D Status than Total Levels?Endocrinology and metabolism clinics of North America · 2017Review
- The DBP Phenotype Gc-1f/Gc-1f Is Associated with Reduced Risk of Cancer. The Tromsø Study.PloS one · 2015Article
- Alpha-fetoprotein: a renaissance.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2013Review
- The alpha-fetoprotein enhancer region activates the albumin and alpha-fetoprotein promoters during liver development.Developmental biology · 2009Article
- An intronic locus control region plays an essential role in the establishment of an autonomous hepatic chromatin domain for the human vitamin D-binding protein gene.Molecular and cellular biology · 2007Article
- The human vitamin D-binding protein gene contains locus control determinants sufficient for autonomous activation in hepatic chromatin.Nucleic acids research · 2006Article
- Evolutionary journey of the Gc protein (vitamin D-binding protein) across vertebrates.Intrinsically disordered proteinsArticle
- Common variants of the vitamin D binding protein gene and adverse health outcomes.Critical reviews in clinical laboratory sciencesReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
The vitamin D binding protein/Gc-globulin (DBP) gene is a member of a multigene cluster that includes albumin (ALB), alpha-fetoprotein (AFP), and alpha-albumin/afamin (AFM). All four genes have structural and functional similarities and map to the same chromosomal regions in humans (4q11-q13), mice, and rats. An accurate physical map of the region encompassing these genes is a prerequisite for study of their respective transcriptional regulation and identification of potential shared regulatory elements. By refining the physical and meiotic maps of the 4q11-q13 region and creating a local PAC contig, the order and transcriptional orientations of these four genes were determined to be centromere-3'-DBP-5'-5'-ALB-3'-5'-AFP-3'-5'-AFM3'-telomere. The ancestral DBP gene was separated from the ALB gene by >1.5 Mb. This organization and spacing establishes a foundation for ongoing functional studies in this region.
Indexed as
Identifiers
10400926PMC310762What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.