Evidence map›Paper›PMID 10400812›Full record

ArticleJournal of virology1999

Resistance of ribosomal protein mRNA translation to protein synthesis shutoff induced by poliovirus.

B Cardinali, L Fiore, N Campioni, A De Dominicis, P Pierandrei-Amaldi

Open access · bronzeAbstract read
In one paragraph

Article in Journal of virology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 18 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

B CardinaliIstituto di Biologia Cellulare CNR, Istituto Superiore di Sanita', Rome, Italy.
L Fiore
N Campioni
A De Dominicis
P Pierandrei-Amaldi
Institute of Cell Biology and Neurobiology · ITIstituto Superiore di Sanità · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Poliovirus infection induces an overall inhibition of host protein synthesis, although some mRNAs continue to be translated, suggesting different translation requirements for cellular mRNAs. It is known that ribosomal protein mRNAs are translationally regulated and that the phosphorylation of ribosomal protein S6 is involved in the regulation. Here, we report that the translation of ribosomal protein mRNAs resists poliovirus infection and correlates with an increase in p70(s6k) activity and phosphorylation of ribosomal protein S6.

Indexed as

Protein BiosynthesisRNA, MessengerHumansPhosphorylationPoliovirusRibosomal ProteinsRibosomal Protein S6Ribosomal Protein S6 KinasesTumor Cells, Culturedribosomal protein L11ribosomal protein L32ribosomal protein L4Ribosomal ProteinsRibosomal Protein S6Ribosomal Protein S6 KinasesRNA, Messenger

Identifiers

PMID10400812
PMCPMC112799
OpenAlexW1733427608

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.