ArticleJournal of virology1999
Cell surface expression of H2 antigens on primary sensory neurons in response to acute but not latent herpes simplex virus infection in vivo.
Article in Journal of virology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 59 citations in OpenAlex.
- Immunological Control of Herpes Simplex Virus Type 1 Infection: A Non-Thermal Plasma-Based Approach.Viruses · 2025Review
- Correlation of β2-microglobulin with postoperative delirium and 3-year mortality undergoing knee or hip replacement surgery: a prospective cohort study.Frontiers in medicine · 2025Article
- Effect of β2-microglobulin in evaluating the severity and prognosis of brain injury: a clinical study.BMC neurology · 2022Article
- Transcriptional Regulation of Latency-Associated Transcripts (LATs) of Herpes Simplex Viruses.Journal of Cancer · 2020Article
- An Ontology Systems Approach on Human Brain Expression and Metaproteomics.Frontiers in microbiology · 2018Article
- Neuronal MHC-I expression and its implications in synaptic function, axonal regeneration and Parkinson's and other brain diseases.Frontiers in neuroanatomy · 2014Review
- Antiviral CD8 T cells recognize borna disease virus antigen transgenically expressed in either neurons or astrocytes.Journal of virology · 2008Article
- CD8 T cell control of HSV reactivation from latency is abrogated by viral inhibition of MHC class I.Cell host & microbe · 2007Article
- Psychological stress compromises CD8+ T cell control of latent herpes simplex virus type 1 infections.Journal of immunology (Baltimore, Md. : 1950) · 2007Article
- CD8+ T cells require perforin to clear West Nile virus from infected neurons.Journal of virology · 2006Article
- The innate immune facet of brain: human neurons express TLR-3 and sense viral dsRNA.Journal of molecular neuroscience : MN · 2006Article
- Latent infection with herpes simplex virus is associated with ongoing CD8+ T-cell stimulation by parenchymal cells within sensory ganglia.Journal of virology · 2005Article
- Inhibition of MHC class I is a virulence factor in herpes simplex virus infection of mice.PLoS pathogens · 2005Article
- Immune responses to RNA-virus infections of the CNS.Nature reviews. Immunology · 2003Review
- Herpes simplex virus-specific memory CD8+ T cells are selectively activated and retained in latently infected sensory ganglia.Immunity · 2003Article
- Recent progress in herpes simplex virus immunobiology and vaccine research.Clinical microbiology reviews · 2003Review
- Herpes simplex virus type 1 and bovine herpesvirus 1 latency.Clinical microbiology reviews · 2003Review
- Article
- Expression of cutaneous lymphocyte-associated antigen by CD8(+) T cells specific for a skin-tropic virus.The Journal of clinical investigation · 2002Article
- In vivo expression of major histocompatibility complex molecules on oligodendrocytes and neurons during viral infection.The American journal of pathology · 2001Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
CD8(+) T lymphocytes and class I major histocompatibility complex (MHC-I) molecules profoundly influence the severity of neuronal herpes simplex virus (HSV) infection in experimentally infected mice. Paradoxically, neurons are classically regarded as MHC-I deficient. However, it is shown here that H2-encoded heavy chains (alphaCs) and their associated light chain, beta2 microglobulin, are present on the surfaces of primary sensory neurons recovered from sensory ganglia within 1 to 2 weeks of HSV infection. During this time, some neurons are found to be tightly associated with T cells in vivo. Prior data showed that termination of productive HSV infection in the peripheral nervous system is not dependent on cell-mediated lysis of infected neurons. Consistent with these data, immunogold electron microscopy showed that the density of cell surface H2 on neurons is an order of magnitude lower than on satellite glia, which is predicted to favor a noncytolytic CD8 cell response.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.