ArticleJournal of virology1999
Proteolytic activity, the carboxy terminus of Gag, and the primer binding site are not required for Pol incorporation into foamy virus particles.
Article in Journal of virology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 28 citations in OpenAlex.
- Human T-cell leukemia virus type 1 uses a specific tRNARNA (New York, N.Y.) · 2024Article
- Review
- Using hyperLOPIT to perform high-resolution mapping of the spatial proteome.Nature protocols · 2017Article
- Foamy virus Gag p71-p68 cleavage is required for template switch of the reverse transcriptase.Journal of virology · 2013Article
- Foamy virus Pol protein expressed as a Gag-Pol fusion retains enzymatic activities, allowing for infectious virus production.Journal of virology · 2012Article
- Role of the foamy virus Pol cleavage site in viral replication.Journal of virology · 2007Article
- Protease-dependent uncoating of a complex retrovirus.Journal of virology · 2005Article
- RNA and protein requirements for incorporation of the Pol protein into foamy virus particles.Journal of virology · 2005Article
- Characterization of the polymerase and RNase H activities of human foamy virus reverse transcriptase.Journal of virology · 2004Article
- Foamy virus envelope glycoprotein is sufficient for particle budding and release.Journal of virology · 2003Article
- Pregenomic RNA is required for efficient incorporation of pol polyprotein into foamy virus capsids.Journal of virology · 2002Article
- Mutation of the catalytic domain of the foamy virus reverse transcriptase leads to loss of processivity and infectivity.Journal of virology · 2002Article
- Specific interaction of a novel foamy virus Env leader protein with the N-terminal Gag domain.Journal of virology · 2001Article
- Identification of a conserved residue of foamy virus Gag required for intracellular capsid assembly.Journal of virology · 2001Article
- A particle-associated glycoprotein signal peptide essential for virus maturation and infectivity.Journal of virology · 2001Article
- Cell-type-specific regulation of the two foamy virus promoters.Journal of virology · 2001Article
- Human foamy virus capsid formation requires an interaction domain in the N terminus of Gag.Journal of virology · 2001Article
- Complex effects of deletions in the 5' untranslated region of primate foamy virus on viral gene expression and RNA packaging.Journal of virology · 2000Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Human foamy virus (HFV) is the prototype member of the spumaviruses. While similar in genomic organization to other complex retroviruses, foamy viruses share several features with their more distant relatives, the hepadnaviruses such as human hepatitis B virus (HBV). Both HFV and HBV express their Pol proteins independently from the structural proteins. However unlike HBV, Pol is not required for assembly of HFV core particles or for packaging of viral RNA. These results suggest that the assembly of Pol into HFV particles must occur by a mechanism different from those used by retroviruses and hepadnaviruses. We have examined possible mechanisms for HFV Pol incorporation, including the role of proteolysis in assembly of Pol and the role of initiation of reverse transcription. We have found that proteolytic activity is not required for Pol incorporation. p4 Gag and the residues immediately upstream of the cleavage site in Gag are also not important. Deletion of the primer binding site had no effect on assembly, ruling out early steps of reverse transcription in the process of Pol incorporation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.